molecular genetics Flashcards
centromere
point where two chromatids are linked and where the microtubules attach
telomere
region of repetitive nucleotide sequences at the end of each chromatid
chromatid
one copy of a duplicated chromosome, generally joined to another copy by centromere
genes
small segment of DNA where its specific nucleotide sequence codes for a polypeptide with a specific amino acid sequence
nucleotide
made up of one phosphate group, one pentose sugar and one nitrogenous base
pentose sugar
rna: ribose sugar
dna: deoxyribose sugar
nitrogenous base
DNA: Adenine, Guanine Cytosine, Thymine
RNA: Adenine, Guanine, Cytosine, Uracil
structure of DNA
- two polynucleotide chains wound around each other to form double helix
- each strand has a sugar phosphate backbone with nitrogenous bases projected at right angles
- nucleotides held together by strong covalent phosphodiester linkages
- polynucleotide strands are antiparallel, one runs in the 5’ to 3’ direction, the other in the 3’ to 5’ direction
- polynucleotide strands held together by hydrogen bonds between nitrogenous bases on opposite strands
complementary base pairing
phenomenon where each type of nitrogenous base on one strand forms hydrogen bonds with a different type of base on the opposite strand
cytosine + guanine (3 H bonds)
adenine + thymine ( 2 H bonds)
central dogma theory
flow of genetic information from dna through rna to protein
transcription
process where a gene is copied to form piece of messenger rna
translation
process where genetic information on the messenger rna is read by a ribosome to synthesize a polypeptide