Molecular Currencies

Question 1

Information processing n cells relies on how many interlinking molecular currencies?

Answer 1

6

Question 2

Names of the 3 most important molecular currencies

Answer 2

Protein-protein interactions
Pots-translational modifications
Subcellular location/concentration

Question 3

Other 3 molecular currencies

Answer 3

Conformation
Enzymatic activity
Small signalling mediators

Question 4

Protein-protein interactions can occur by what 2 mechanisms?

Answer 4

Protein binding by broad interaction surfaces and protein binding by short, linear peptides

Question 5

Protein binding by broad interaction surfaces

Answer 5

Protein binding by broad interaction surfaces and

Question 6

Most common molecular currency

Answer 6

Protein-protein interactions

Question 7

Example of protein binding by broad interaction

Answer 7

G proteins ***

Question 8

Protein binding by short linear peptides

Answer 8

One bind surface consists of short, linear pende surface
Fits into corresponding groove on other protein
‘Docks’

Question 9

Example of protein binding by short linear peptides

Answer 9

SH2 domains binding to phosphorylated tyrosine residues