molecular biology of Hb synthesis Flashcards
the globin are a family of …….. , which are thought to share in a common …………..
globular protein
ancestor
globin originated first as …….in ……..
one gene
one chromosome
list events that globin gene undergoes to produce the current diversity of the polypeptide chain present now
- duplication
- transposition
- overtime ( again and again )
duplication occur on ……. to produce …….
the same chromosome
2 identical copies of the gene
…….. occur to both genes so that some ……. between them occur . however because they are still has more than …….
in their AA sequences , they are still expressing …….
-mutation
-dis- similarity
-95% similarity
-protein with same molecular structure ( alpha helices folded the same way )
illustrate transposition
these 2 copies of the gene became on 2 different chromosomes ( chromosomes 11 & chromosome 16 )
what’s meaning of over time ( gain and gain )?
further duplication and mutation events occurred so that many versions of these globin genes arose ( γ , δ , ε )
α gene family has …….. separated by ……
3 exons - 2 introns
-the α gene cluster on chromosome…..
contain ……..gene for the α globin chains , also contain the……..that’s expressed early in development as an ………
- globin gene families also contain ……. that aren’t expressed , that is , their genetic information …………..to produce globin chain , called ……..
-16
2
ζ gene
α globin like component of embryonic Hb
- globin like gene
is not used
pseudogenes
β gene family has ……separated by ……
3 exons - 2 introns
A…….. located on chromosome ……. for β globin chain .
single gene
11
there are an additional 4 β globin like genes. illustrate
1.ε gene ( like ζ gene) expressed in embryonic development
2. two gama gene ( Gγ , A γ) expressed in HbF
3. δ gene codes for the globin chain found in minor adult HbA2
