Molecular Biology: Genetics of Cardiovascular Disease Flashcards
1
Q
What is the threshold model assumption?
- What type of heart disease can be attributed to this?
A
2
Q
What is the criteria to define a multifactoral inheritance risk?
A
3
Q
What is concordance?
- What is concordant mean?
- What does discordant mean?
A
4
Q
CV Conditions
- What are the 4 HTN genetic disorders and what mutation is each associated with?
A
5
Q
What are the 2 genetic cardiomyopathies and what genes are associated with them?
A
6
Q
What are the genes implicated in long QT syndrome?
A
7
Q
Familial hyperchylomicronemia aka Burger Grutz
- What inheritance does it display?
- What molecule decreased?
- What happens to TAGs?
- What location has high incidence?
- What are 2 conditions assoicated with it?
A
8
Q
- What are the 3 monogenic disorders of lipoprotein metabolism that ARE NOT recessive?
- Which one has PCSK9 implicated?
- Which one has incomplete dominance?
A
9
Q
Monogenic Disorders of Lipoprotein Metabolism
- What are the 3 recessive disprders?
- Which one affects ApoEe4?
- Which one affects chylomicron remnants?
- Which one affects ABCA1 protein?
- Which one has low HDL levels?
- Which one affects MTTP?
- Which one affects vitamin absorption?
- Which one has star shaped RBCs?
A
