Molecular Biology Flashcards
Name the drugs that cause drug induced lupus
Isoniazid (tb drug)
Hydrolazine (vasondilatador for high blood pressure)
Procainamid (anti arritmic)
What’s an histone
DNA protein (H1; H2A; H2B; H3; H4)
H1 keeps them together : the rest binds and form octameter (8 histones)
What causes drug induced lupus?
Anti histones antibodies
Which aa gives Nitrogen to Purines?
Glutamine (2 N)
Aspartate ( 1N to the 6th ring)
Glycine (carbons and N)
What are the carbon sources of Purines?
CO2 (1 in 6C ring)
Tetrahydrofolate (2; 1 to each ring)
Glycine (2; each ring)
Drugs that inhibit IMP dehydrogenase
Ribavirin
Mycophenolate
Antiviral that blocks conversion of IMP to GMP
Rivabirin,
Inhibits guanine nucleotides
Immunosuppressant that inhibits IMP dehydrogenase in white cells
Mycophenolate
Chemotherapy agent that mimics hypoxantine/ guanine to inhibit the novo synthesis
Azathioprine -> 6-mercaptopurine [6-mp])
Creates thioniosinic acid
(Decreases DNA synthesis by decreasing IMP/GMP/AMP)
Enzyme deficient or disfunctional in the severe combined immunodeficiency syndrome
Adenosine deaminase
(Purine -Adenine- breakdown pathway)
Inhibits xanthine oxidase
Allopurinol
(Tx for gout )
Lesch Nyhan syndrome
X linked deficiency of HGPRT
Excess De Novo synthesis (PRPP -IMP)
Lesch nyhan syndrome
Source of C an N of pyrimidine rings
Carbamoil Phospate - 1 C and 1 N
Aspartate - 3 C and 1 N
Defect in UMP synthase
Orotic aciduria