Molecular basis

Question 1

Even tho the disc of —— by —- and —– by —- were almost at the same time, but that the —-acts as the genetic material took long to be —– and –

Answer 1

Nuclein- Meischer
Principle of inheritance- Mendel

DNA, discovered and proven

Question 2

By —, the quest for determining the —— had reached the molecular level

Answer 2

1926
mechanism of genetic inheritance

Question 3

previous dic by —,— and —- and numerous other scientists had narrowed the search to chromosomes located in —–
but, the q of what —– the genetic material had not been answered

Answer 3

Mendel, Sutton, Morgan
nucleus of MOST cells

molecule was actually

Question 4

In —-, Frederick — in a series of exps with —– (bac responsible for —) witnessed miraculous — in the bac.
During the course of his exp, a living organism (bac) had —-

Answer 4

1928, Griffith
Streptococcus pneumoniae
pneumonia
transformation

changed in physical form

Question 5

when streptococcus pneumoniae (—-) bacteria are grown on —-, some produce —- colonies (S) while others produce — colonies (R)

Answer 5

pneumococcus
culture plate
smooth, shiny
rough

Question 6

S strain bac have a —– coat while R strain do not

Answer 6

mucous (polysaccharide)

Question 7

Mice infected with S strain (—) — from pneumonia but mice infected with R strain —- pneumonia

Answer 7

virulent- die from
do not develop

Question 8

Griffith was able to kill bac by

Answer 8

heating them

Question 9

heat killed —- did not kill the mice, but a mixture of heat killed —- and —- killed the mice
moreover, griffith recovered —- from the dead mice

Answer 9

S strain
S strain and live R
living S bac

Question 10

Griffith concluded that

Answer 10

R strain bac had somehow been transformed by the heat killed S strain bac

Question 11

Some —– transferred from heat killed s strain had enabled r strain to —-

This must be due to the tranfer of —-. however the — nature of —- was not defined from his exp

Answer 11

transforming principle
synthesise a smooth polysaccharide coat and become virulent

genetic material
biochemical nature, genetic material

Question 12

Prior to the work of —-, —-, —- (—–) the genetic material was thought to be —-
The worked to determine —— in griffiths exp

Answer 12

Oswald avery, Maclyn Mccarty, Colin Macleod
(1933-44)
protein

biochemical nature of transforming principle

Question 13

They purified —- (—) from the heat killed S cells to see which ones could transform live R cells into S cells

Answer 13

biochemicals (proteins, dna, rna)

Question 14

they disc that — alone from s bac caused r bac to be transformed

Answer 14

dna