Module 7: PVD Flashcards
Bates Ch. 12
What surrounds the lumen of all blood vessels?
The intima, a single continuous lining of endothelial cells with remarkable metabolic properties.
What does intact endothelium do?
Synthesizes regulators of thrombosis like prostacyclin, plasminogen activator, and heparin-like molecules. It produces molecules such as Von Willebrand factor and plasminogen activator inhibitor. Modulates blood flow and vascular reactivity through synthesis of vasoconstrictors like endothelia and angiotension converting enzyme and vasodilators such as nitric oxide and prstacyclin.
What does the intimal endothelium do?
Regulates immune and inflammatory reactions through elaboration of interleukins, adhesion molecules, and histocompatibility antigens.
Which part of the vessel helps to accommodate blood pressure and flow?
Media
What are the immediate branches of the aorta?
Examples: pulmonary, common carotid, and iliac arteries.
Examples of muscular arteries:
Coronary and renal
What helps to propagate arterial pulsatile flow?
The elastic recoil and smooth muscle contraction and relaxation in the media of large and medium sized arteries.
The leg veins are more susceptible to what?
irregular dilation, compression, ulceration, and invasion by tumors.
How much of the blood return do the deep veins carry?
90%
Which veins connect the superficial venous system with the deep venous system?
The perforating veins.
What do cells within the lymph nodes do?
Engulf cellular debris and bacteria and produce antibodies.
What are the only nodes accessible in a physical exam?
cervical, axillary, and nodes in the arms and legs.
What are the two groups of the superficial inguinal nodes?
The horizontal group which lies in a chain high in the anterior thigh below the inguinal ligament and the vertical group which clusters near the upper part of the saphenous vein and drawings a corresponding region of the leg.
What does the horizontal group help drain?
Lower abdomen, buttock, external genitalia (NOT TESTES), anal canal and perianal area, and lower vagina.
What are some common or concerning symptoms of patients?
Pain in the arms or legs, intermittent claudication, cold, numbness, pallor in the legs along with hair loss, swelling in the calves, legs, or feet, color change in fingertips or toes in cold weather, and swelling with redness or tenderness.
What is peripheral arterial disease (PAD)?
It refers to stenotic, occlusive, and aneurysmal disease of the aorta, its visceral arterial branches, and the arteries of the lower extremities, exclusive of the coronary arteries.
________ can cause symptomatic limb ischemia with extortion.
Atherosclerosis; distinguish this from spinal stenosis, which produces leg pain with exertion that may be reduced by leaning forward (stretching the spinal cord in the narrowed vertebral canal) and less readily relieved by rest.
What is pain or cramping in the legs during exertion that is relieved by rest within 10 minutes?
Intermittent claudication.
Hair loss over the anterior tibiae occurs with ______ arterial perfusion.
Decreased; Dry or brown black ulcers from gangrene may ensue.
Do people with PAD report a lot of symptoms?
NO so it is pertinent to ask specific questions about symptoms. especially in patients >50 years and those with risk factors such as smoking, diabetes, hypertension, elevated cholesterol, CAD.
Symptom location suggests the site of arterial ischemia:
Buttock, hip; Aortoiliac Erectile Dysfunction; Illiacpudendal Thigh; Common femoral or Aortoiliac Upper calf; Superficial femoral Lower calf; Popliteal Foot; Tibial, peroneal
What should you ask about?
Fatigue, aching, numbness, or pain that limits walking or exertion to the legs, erectile dysfunction, any poorly healing or non healing wounds of the legs or feet, pain at rest in the lower leg or foot and changes when standing or supine, abdominal pain after meals with “food fear” and weight loss.
What do abdominal pain, “food fear”, and weight loss suggest?
Intestinal ischemia of the celiac or superior or inferior mesenteric arteries.
What is the prevalence of AAA in first degree relatives?
15%-28%