Module 7 Pharmacology - Anti-inflammatory/Anti-infective/Antibiotics Flashcards
aspirin
Onset: 5-30 min
Peak: 1-3 hr
Duration: 3-6 hr
- Therapeutic and pharmacologic class (2,1)
- Indications (2)
- Contraindications (2)
- Antidote (4)
- Mechanism of action (1)
- Common and life-threatening side effects (3,3)
- Assessment and safety (3)
Trade Names: ASA, acetylsalicylic acid
Ther. Class.: antipyretic, nonopioid analgesic
Pharm. Class.: salicylate
Indications:
- Inflammatory disorders (RA, OA)
- Fever
Contraindications:
- Bleeding disorders or thrombocytopenia
- Hypersensitivity
Mechanism of Action:
-Inhibits production of prostaglandins
Therapeutic Effect:
- Reduces inflammation
- Reduces fever
Route: PO, rectal
Most Common Side Effects:
GI: dyspepsia, epigastric distress, nausea
Life-threatening Adverse Reactions:
GI: GI BLEEDING
Misc: ANAPHYLAXIS, LARYNGEAL EDEMA
Antidote/Emergency Treatment:
- Activated charcoal
- Stomach pump may be considered if overdose taken within 1 hour of treatment
- IV D5W (to increase urine output)
- Sodium bicarbonate (to increase urine pH, thereby increasing ASA elimination in urine)
Safety/Monitoring:
- Those with asthma, allergies, and nasal polyps are at increased risk for hypersensitivity reaction
- Those allergic to tartrazine are at increased risk for hypersensitivity reaction
- Monitor for signs of toxicity (tinnitus, headache, altered mental state, hyperventilation, diaphoresis)
Interactions:
- Increased risk of bleeding with heparin-like agents and thrombolytic agents
- Increased risk of GI irritation with use of other NSAIDs
- Ibuprofen may negate cardioprotective antiplatelet effect of low-dose ASA
- May reduce effect of diuretics and ACE inhibitors
Metabolism and Excretion:
- Metabolized by liver
- Excreted mainly through kidneys (depends on urine pH)
Evaluation/Desired Outcomes:
-Increased joint movement (may take 2-3 weeks for max effect)
Patient Education:
- Caution patient to avoid alcohol with this medication to lower risk of GI bleed (no more than 3 glasses/day)
- Caution patient to avoid concurrent use of acetaminophen or other NSAIDs unless instructed by provider
naproxen
Taken for anti-inflammatory effect…
Onset: 2 weeks
Peak: 2-4 weeks
Duration: ?
- Therapeutic and pharmacologic class (3,0)
- Indications (2)
- Contraindications (5)
- Antidote/Emergency Treatment (2)
- Mechanism of action (1)
- Common and life-threatening side effects (6,4)
- Assessment and safety (3)
Trade Names: Aleve, Naprosyn
Ther. Class.: NSAID, antipyretic, nonopioid analgesic
Pharm. Class.: none
Indications:
- Inflammatory disorders (RA, OA)
- Fever
Contraindications:
- Hypersensitivity and cross sensitivity to other NSAIDs
- Active GI bleed
- Ulcer disease
- Periop pain control surround CABG
- Nursing mothers
Mechanism of Action:
-Inhibits prostaglandin synthesis
Therapeutic Effect:
- Suppress inflammation
- Reduce fever
Route: PO
Most Common Side Effects:
CNS: dizziness, drowsiness, headache
GI: constipation, dyspepsia, nausea
Life-threatening Adverse Reactions:
CV: HF, MI, CVA
GI: DRUG-INDUCED HEPATITIS, GI BLEED
Misc: ANAPHYLAXIS, STEVENS-JOHNSON SYNDROME
Antidote/Emergency Treatment:
- Follow protocol for NSAID overdose
- Activated charcoal
- Due to high protein binding, hemodialysis is not effective; alkalization of urine may be effective if done within 4 hours of overdose
Safety/Monitoring:
- Those with asthma, aspirin allergy, and nasal polyps are at increased risk for hypersensitivity reaction
- Assess for rhinitis, asthma, and urticaria
- Assess ROM 1-2 hours after administration
Interactions:
- Concurrent use with aspirin may decrease effectiveness
- Increased risk of bleeding with anticoagulant/antiplatelet drugs
- Adverse GI side effects with aspirin, corticosteroids, NSAIDs, or alcohol
- May decrease effectiveness of antihypertensives and diuretics
- May increase risk of hypoglycemia with insulin
Metabolism and Excretion:
-Mostly metabolized by liver
Evaluation/Desired Outcomes:
- Improved joint mobility in 2-4 weeks
- Reduction of fever
Patient Education:
- Caution patient to avoid concurrent use of alcohol, aspirin, acetaminophen or other OTC meds without consulting a health care professional
- Higher doses won’t increase therapeutic effect, but may increase side effects
- For rapid effect, take 30 minutes before or 2 hours after meal; to decrease GI side effects, take with meal
ibuprofen
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
ketoralac
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
hydrocortisone
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
methylprednisolone
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
prednisone
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
triamcinolone
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
alcohol
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
povidone-iodine
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
chlorhexidine
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
hydrogen peroxide
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
ampicillin
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
dicloxacillin
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
cephalexin
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
cefuroxime
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
ceftriaxone
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
cefepime
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education:
ceftaroline
Onset
Peak
Duration
- Therapeutic and pharmacologic class (#)
- Indications (#)
- Contraindications (#)
- Antidote (#)
- Mechanism of action (#)
- Common and life-threatening side effects (#)
- Assessment and safety (#)
Trade Names:
Ther. Class.:
Pharm. Class.:
Indications:
Contraindications:
Mechanism of Action:
Therapeutic Effect:
Route:
Most Common Side Effects:
Life-threatening Adverse Reactions:
Antidote:
Safety/Monitoring:
Interactions:
Metabolism and Excretion:
Evaluation/Desired Outcomes:
Patient Education: