Module 7 Flashcards
The brain's blood dependence: brain cells depend on: blood supplies brain cells with: blood also removes ? from? the cells of the brain have no mechanism to ? they have complete dependence on
uninterrupted and oxygenated blood
nutrition
- glucose
- oxygen
metabolic waste (carbon dioxide) from nerve cells
-store glucose or oxygen for later consumption/ blood flow
brain blood flow and stroke
-without adequate blood supply, the brain can only function ? before the cell bodies are
interruption of blood flow for 4-6 minutes results in?
- damage occurs to the ?
- the area that surrounds the core infarct is called the
- neurons in the area of the prenumbra may survive for about ? without alternate circulation, and up to ? if there is some degree of collteral blood supply
for a few minutes/ cell bodies are irreversibly damaged
irreversible brain damage
- core cells that are the center of where the infarction occured
- ischemic penumbra
20 minutes/ 6-8 hours
Acute stroke:
two types
ischemic: inadequate blood flow to the brain results in ?
hemmorhagic:
- rupture of a blood vessel
- blood which is toxic to brain tissue
- blood also causes swelling of ? swelling can further restrict ?
- issue with tissue damage and potential increasedintra cranial pressure due to the ? as well as ?
damage to the brain tissue
causes bleeding in the brain
- collects in brain tissue
- brain tissue/ blood flow to other neighboring brain tissue
- bleed itself/ swelling as a reaction to the blood
Comprehensive Stroke Center:
hospital certified by the ?
Early management of acute ischemic stroke: a guideline for ?
this designation/certificated is given to center that are able to:
.. and… treat all strokes utilizing ?
-provide ? for blood clot removal
-provide
American Heart Association/american stroke association stroke leadership council
healthcare professionals from the american heart association/american stroke association
- quickly and effectively/ medications to resolve blood clots
- catheter based procedures
- neurosurgical services
Treatment for ischemia in the brain:
what restores blood flow:
-
-
tPA (tissue plasminogen activator) - drug
thrombectomy: procedure (vascular/neurosurgery) - larger clot in larger vessel
Tissue plasminogen activator: tPA (generic name is ? ) approved by FDA in ? -dissolves blood clots that are -given to patients via -administered within ? limits risk of ? .... consider timing of
alteplase/ 1996 blocking blood flow to the brain - IV -3 hours of symptoms onset -brain damage and functional impairment -hemorrhage (risk and contraindication) -SLP intervention
Thrombectomy:
in some hospitals can be completed up to? (if imaging shows ?)
-more typically, the window is … from symptom onset (with assumption that damage to neural tissue will not be improved by ?)
time of onset is tricky calculaton
-…. onset
-variation in ?
24 hours after onset of ischemic stroke ( there would be therapeutic benefit)
6 hours (intervention)
unwitnessed
A&P of individual patients
Thoughts about stroke and COVID-19:
risk of worse outcomes with COVID-19 patients with history of ?
risk of stroke with COVID:
-two studies ad meta-analysis suggests that stroke is associated with ?
covid-19 itself may contribute to development of?
-prevalence of ischemic stroke is ?
true association remains ?
further investigation and more consistent covid screening ?
consider the non-COVID patient: risk of greater ? lasting deficits from stroke as patients are less likely to ?
stroke
2.5 fold increase in likelihood of severe COVID-19 with a trend in increased mortality
vascular events
-1.6%
unclear
-needed
injury/ seek medical treatment due to COVID
Acute Ischemic Stroke and COVID-19 an analysis of 27, 676 patients:
investigated ?
patients with covid with or without ischemic stroke and
acute ischemic stroke patients with and without ?
risk factors, comorbidities and outcomes between
covid
total of 103 patients developed ? among 8136 patients with covid
among all patients with covid the proportion of patients with hypertension, diabetes, hyperlipidemia, atrial fib, and congestive heart failure ?
acute ischemic stroke was associated with discharge to ?
acute ischemic stroke
was significantly higher among those with acute ischemic stroke
destination other than home or death
Acute ischemic stroke was infrequent in patients with ? and usually occurs in the presence of other ?
the risk of discharge to destination other than home or death increased 2-fold with occurence of ?
cardiovascular risk factors
acute ischemic stroke in patients with COVID 19
Stroke - intervention/facilities: ... care Subacute care: depends upon ? -consider -... patients sadly, can depend upon options: ... rehab -... rehab long-term ? home (... considerations) - -
acute care
level of function
- rehab needs
- ambulatory patients
finances
acute rehab (inpatient rehab) -sub-acute rehab (SNF) -care facility (frequently SNF first) (safety considerations) -home health -outpatient rehab services
Brain tumors:
a neoplasm is an area of uncontrolled ?
tumors result from an improper expression of ? and a decrease in expression of ?
-angiogenesis also promotes ? this is the formation of new blood vessels which promotes?
tumors in the brain can be ?
metastatic tumors in the brain are frequently metastasis of cancers including ?
they can also come from ? and from ?
spread results from cells traveling through the ?
growth of body tissue/ includes the glia
oncogenes (coding proteins involved with cellular growth) / tumor supressor genes
tumor growth / growth of tumor tissue
primary or metastatic
breast, lung, colon/ lymphomas and melanoma
lymphatic system or blood vessels
Neuroglial cells- functions astrocytes (CNS) -form a complete ? -contribute to the blood-brain barrier by restricting ? form ?
Oligodendrocytes:
form ? around axons in the CNS
microglia:
migrate to a site of ?
ependymal cells:
form the ?
Schwann cells (PNS) -form the ? constitute ... around fibers in the PNS
lining around the surface of the brain
- permeability of ionic substances across the blood vessels
- scars around a cerebral infarct
myelin sheaths
brain lesion and engulf cellular debris to remove it
membranous lining of the ventricular cavity
myelin sheath around axons in the PNS
fibrous connective tissue
Brain Tumors Can Be: are staged in grades (1-4) Grade 1: Grade II: Grade III: Grade 4:
non-cancerous or very slow growing
cancerous but slow growing (cells look closer to normal)
cancerous y grow faster than grade 1 and II (more cell abnormalities)
fast growing with greater cell abnormalities (may also have necrotic tissue; develop own blood vessels, spread to other parts of brain)
Brain Tumour Types:
astrocytoma:
arise from
the worst brain tumour is the ?
ependymoma:
arise from
oligodendroglioma:
arise from ? frequently found in ?
astrocytes Glioblastoma (GBM) - a type of astrocytoma
ependymal cells lining the ventricles
oligodendrocytes - frequently found in the frontal region of the adult brain
Brain Tumors (Non-malignant)
Meningioma: arises from ?
usually ?
Acoustic neuroma (vestibular ? ) arise from the ? and are typically located at the
symptoms can include: and can cause other ?
-…,…,…
cause ?
Pituitary adenomas:
cause ? and can produce ? due to ?
meninges
non-malignant
schwannoma
-nerve sheath/ cerebllopontine angle
impaired hearing acuity and equilibrium / other deficits (tumour and post-op)
-facial weakness, dysphagia, dysphonia
hydrocephalus (obstruct fourth ventricle)
hormonal dysfunction / visual deficits / compression of optic chiasm
Diagnosis and TX planning: ... planning is frequently completed at a ? typically conducted ? include: - - - - - - -
medical/surgical / neuro tumour board meeting
weekly
- neuroradiologist
- pathologist
- medical oncology
- radiation oncology
- neurosurgery
- neurology
- mid-level providers
- SLP
Treatment options:
medical ?
-
radiation?
- … therapy
- several ?
neuro?
all of the
what will?
… of the above
oncology
-chemotherapy
radiation oncology
- radiation therapy
- several types
neurosurgery
- all of the above
- timing be?
- none of the above
SLP role: Communication ? and swallowing ? pre-treatment ? post-surgery intervention during ? as needed post-treatment ? -treatment as -... participation in ?
function baseline measures functional measures medical and radiation oncology treatment, as needed functional meaurements -appropriate -education awake craniotomy
Dementia: an ? term a group of disorders that affect affects: - - -
2 types:
… dementia
… dementia
…
umbrella term
brain function
- thinking
- behavior
- ability to complete ADL
cortical dementia (alzheimers)
sub-cortical dementia (Parkinsons dementia)
combo
Types of dementia:
alzheimers:
- the most common
- accounts for ?
.. dementia:
second most
-accounts for
Lewy body:
accounts for
frontotemporal:
accounts for
other
form of dementia
40-70%
vascular dementia
- common from
- 15-25%
2-20%
2-4%
brain injury ETOH HIV PD HD creutzfeldt jakob
Role of SLP:
communication:
assessment of
educate?
-to maximize
intervention with SLP should be ?
Swallowing: assessment of ? -may be best to ask what will be -establish consider treatment may be ? due to ?
current function
-medical professionals and family members
strategies
-environmental
-comm. function
relatively short in duration
- current function
- done regarding results
- least restrictive PO diet
- patient and family wishes
- limited / cognitive comm. dysfunction