module 6 flashcards

1
Q

Thrombus

A

blood clot

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2
Q

Embolus

A

blood clot that is moving throughout the bloodstream

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3
Q

Heparin route

A

SubQ or IV drip

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4
Q

Heparin dosage

A

10-40,000 units

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5
Q

Heparin frequency

A

BID or TID

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6
Q

Heparin MOA

A

Turns off coagulation pathway and prevents clots from forming. inactivate thrombin and factor xa

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7
Q

Heparin Adverse effects

A

Bleeding, hematoma, anemia, thrombocytopenia, heparin induced thrombocytopenia (HIT)

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8
Q

Heparin antidote

A

Protamine Sulfate

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9
Q

Heparin contraindications

A

allergy, acute bleeding process/risk

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10
Q

Heparin interactions

A

Aspirin, NSAIDS, oral anticoags, antiplatelets, thrombolytics (all lead to increased bleeding)

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11
Q

heparin nursing actions

A

monitor vital signs, observe for bleeding ( increased hr, decreased bp, bruising, black tarry stools), monitor aptt

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12
Q

Enoxaparin route

A

parenteral only, prefilled syringes with air bubble

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13
Q

Enoxaparin dosage

A

40mg

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14
Q

Enoxaparin frequency

A

Once a day

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15
Q

Enoxaparin MOA

A

inactivate factor xa only

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16
Q

Enoxaparin adverse effects

A

Black box warning for spinal hematomas if pt has epidural catheter

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17
Q

Enoxaparin antidote

A

protamine sulfate

18
Q

Enoxaparin contraindications

A

indwelling epidural catheter, allergy, acute bleeding process/risk

19
Q

Enoxaparin interactions

A

heparin

20
Q

Warfarin route

A

oral

21
Q

Warfarin dosage

A

dependent on patients INR

22
Q

Warfarin frequency

A

same time everyday

23
Q

Warfarin MOA

A

Inhibit vitamin K synthesis by bacteria in the GI tract which then inhibits clotting factor production

24
Q

Warfarin adverse effects

A

bleeding, NV, abdominal cramps, skin necrosis, purple toes syndrome

25
Q

Warfarin antidote

A

vitamin K, when given IV there is a risk for anaphylaxis so you give it diluted and over 30 mins

26
Q

Warfarin contraindications

A

Pregnancy, allergy, acute bleeding process/risk

27
Q

Warfarin interactions

A

acetaminophen, aspirin, NSAIDS, gingko, broad spectrum antibiotics, barbiturates, rifampin, phenytoin, statins, garlic, st john’s wort

28
Q

Warfarin nursing actions

A

administer the oral dose same time each day, assess carefully for excessive bruising/unusual bleeding, monitor INR lab values (2-3 goal range), do not fluctuate diet.

29
Q

Clopidogrel route

A

PO

30
Q

Clopidogrel dosage

A

300mg loaded dose, 75mg once daily

31
Q

Clopidogrel frequency

A

daily

32
Q

Clopidogrel MOA

A

alter the platelet membrane so it can’t receive the signal to form a clot

33
Q

Clopidogrel adverse effects

A

black box warning for patients with genetic abnormalities, chest pain, edema, flu like symptoms, headache, dizziness, fatigue, abdominal pain, diarrhea, nausea, epistaxis, rash, pruritus

34
Q

Clopidogrel contraindications

A

drug allergy, thrombocytopenia, active bleeding, leukemia, traumatic injury, gi ulcer, vitamin k deficiency, recent stroke

35
Q

Clopidogrel Interactions

A

dipyridamole, amiodarone, calcium channel blockers, NSAIDs, proton pump inhibitors

36
Q

INR

A

international normalized ratio is a calculation based off of pt time

37
Q

aPTT

A

Activated Partial Thromboplastin Time.

Measures how long it takes for a blood clot to form

38
Q

PT

A

measures how long it takes for a blood clot to form in a blood sample

39
Q

Anticoagulant

A

preventing/ delaying blood coagulation (Heparin, Enoxaparin, Warfarin)

40
Q

Antiplatelet

A

inhibit platelet aggregation (Clopidogrel)

41
Q

Prophylactic use

A

prevention

42
Q

Combination therapy

A

never give heparin in combo with enoxaparin, clopidogrel is given in combo with aspirin