Module 6 Flashcards
Psychotic disorders are
disturbances of thought content and/or process and signal a departure from reality, often accompanied by a combination of hallucinations and delusions, disorganized thinking (speech), disorganized or abnormal motor behavior (including catatonia), and negative symptoms
annual health-related expenses of someone with chronic schizophrenia averaged more
than $15,000
schizophrenia
acute or insidious onset
symptoms for six months, at least 2 or more positive or negative symptoms for 1 month. one positive symptom must be delusion, hallucination, disorganized speech
schizoaffective disorder
2 weeks or longer with psychotic symptoms in absence of mood symptoms, negative symptoms less severe
schizophrenia age of onset
typically during adolescence or early 20s, earlier in men than women
teens with schizophrenia have this risk of attempted suicide
50%
plays role in poor health outcomes with schizophrenia
poor engagement in health maintenance initiatives such as cancer screenings, exercise, nutrition, tobacco cessation, and identification of other comorbid chronic medical diseases
risk factors schizophrenia
immigration, living in an urban area, OB complications, late winter/ early spring births, advanced paternal age
transmitter systems that are likely involved in patho of schizophrenia
dopamine
glutamate
GABA
acetylcholine
4 symptom clusters in schizophrenia
positive symptoms
negative symptoms
cognitive impairments
affective disturbances
Positive symptoms refer to
the “active” qualities of these symptoms that are abnormal and are synonymous with psychosis. Positive symptoms include delusions, hallucinations, disorganized thinking (speech), and grossly disorganized or abnormal behavior (catatonia). Delusions are the hallmark of positive symptoms,
Delusions are
fixed beliefs that are not amenable to change despite conflicting evidence. They can include persecutory, referential, somatic, religious, or grandiose themes.
Hallucinations are
sensory impressions without basis of reality. They can be vivid and clear to the individual experiencing them and may occur in any sensory modality such as auditory, visual, somatic, olfactory, or gustatory, with auditory followed by visual hallucinations most common.
Tangentiality
—getting off topic without answering questions appropriately
Circumstantiality
—will answer question in markedly roundabout manner
Derailment
—switching topics without a logic sequence
Neologisms
—creation of new, idiosyncratic words
Word salad—
words are placed together without any sensible meaning
Negative symptoms represent
diminished or a lack of normal characteristics—diminished emotional expression and avolition
Avolition represents
decline in motivated self-initiated purposeful activities. This encompasses loss of affective responsiveness, verbal expression, and communication, personal and social motivation, and enjoyment
Cognitive impairments include
difficulties with memory, attention, psychomotor speed, and executive function. Cognitive impairments, along with negative symptoms, are the most common contributors to disability in schizophrenia.
Affective disturbances
, which are difficulties with mood and affect, are seen with schizophrenia. Depression and anxiety can be detected before, during or after a psychotic episode, and providers must be alert for risk of suicide
pharm therapy schizophrenia
antipsychotics, early intervention is key. effective in addressing positive symptoms but not negative and cognitive symptoms
best way to treat negative and cognitive symptoms
CBT in combo with meds
pts with first episode of schizophrenia
typically more responsive to meds than multiple episodes
typical antipsychotics
effective, but have more motor system side effects
atypical antipsychotics
equally effective to typical
reduce positive symptoms
less likely to have motor side effects
associated with weight gain, metabolic disturbance
Extrapyramidal symptoms (EPS)
are potentially troubling side effects of antipsychotics and include Parkinson-like symptoms, akathisia (an inability to sit still), and dystonia (akin to muscle cramps). In some cases, tardive dyskinesia develops
Persons experiencing a first episode should remain on the antipsychotic medication for at least
18 months.
Currently the manufacturer recommends evaluation of cataracts at baseline and every 6 months for patients taking
quetiapine (Seroquel
Patients with schizophrenia have an average life span that is reduced by
20 years compared with population norms,
OCD
OCD is characterized by the presence of obsessions, compulsions, or both. Only one category of symptoms is required for diagnosis. Distress is present or acts are time consuming or significantly affects normal routine
Obsessions are
recurrent and persistent thoughts, urges, or images that are experienced as intrusive and unwanted.
Compulsions are
repetitive behaviors or mental acts that an individual feels forced to perform due to either an obsession or strict rules of conduct. Compulsions help to temporarily decrease anxiety from obsessions and thus, over time become reinforced
OCD onset
acute, typically after significant stressful event
pediatric autoimmune neuropsychiatric disorders associated with group A beta-hemolytic streptococcal infection (PANDAS)
haracterized by rapid onset and other neuropsychiatric symptoms, including tics, restricted eating, anxiety, and/or irritability. It is thought to be triggered by a throat infection or other illness, leading to the production of autoimmune antibodies against streptococci, which also cross-react with the basal ganglia. This cross-reaction is thought to result in neuropsychiatric symptoms
OCD most common obsessions
The most common obsessions are fears of contamination, pathological self-doubt, intrusive thoughts, and symmetry.
1st line treatment OCD
SSRI, higher doses and trials (12 weeks) required
CBT
Body dysmorphic disorder
Preoccupation with perceived defects or flaws in physical appearance, leading to repetitive behaviors or mental acts.
Excoriation (skin-picking) disorder
Repeated skin picking results in skin lesions. The most common areas impacted are the face, arms, and hands
Hoarding disorder
Persistent difficulty discarding or parting with objects, regardless of their actual value or importance, due to a perceived need to save them and distress associated with discarding them.
Trichotillomania (hair-pulling) disorder
Recurrent hair-pulling from any part of the body resulting in hair loss. There are repeated attempts to stop or decrease the hair pulling.
OCD treatment as last resort
DBS, must be chronic severe and treatment resistant