Module 4.4 (Palliative Care) Flashcards

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1
Q

Definition of Palliative Care

A

“Palliative care is an approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial and spiritual.”

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2
Q

Essenital elements of palliative care?

A

Affirms life and views dying as a natural/normal process of life

Neither hastens nor postpones death

Uses a team approach to address the

> psychological

> social

> spiritual

aspects of patient care

  • Provides relief from distressing symptoms
  • Offers support to help patients live as actively as possible until death
  • Uses a team approach to support the patient & family during illness, death & bereavement
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3
Q

Who are the people included when considering palliative care?

People with a progressing life-limiting or life-threatening illness

A

Will include people with:

– metastatic cancer

– HIV/AIDS

– end-stage organ disease

– progressive degenerative neurological conditions

– older people dying as a consequence of the ageing process

>not dependent on medical diagnosis –> determined by a person’s needs

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4
Q

What can someone with palliative care “also have”?

A

People with a progressing life-limiting or life-threatening illness

Who also have:

  • increasing disability
  • frequent hospitalisation
  • and/or decreasing benefit from therapies

>includes people of all ages from perinatal to the very elederly

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5
Q

Wha are some patterns of functional decline?

A

Sudden death

Malginant disease

Organ failure

Frailty

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6
Q

What does continuum of care encompass?

A
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7
Q

What is a palliative care approach?

A

Priumary health care –> primary care needs

> effectively meets their needs

Intermediate needs

>exacerbation of symptoms

>access to a specialist pallaitve care for advice

Complex needs

>requires more attention than primary caregivers can provide

>referral to specialist

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8
Q

What is specialist pallaitive care?

A
  • symptoms that require specialist assessment/management … beyond capacity of the primary care team to manage optimally
  • patient and/or their family has psychological, social or spiritual needs that require specialist assessment
  • patient is dying and the primary care team requires additional support and/or advice
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9
Q

How to access specialist care?

A

Home

  • Silver Chain Hospice Care Service

Residential Care Facility

  • Metro Ambulatory Palliative Care Service

Hospital

  • Consultancy Services
  • FSH, KEMH, PMH, RHCS, RPH, SCGH, SJoG

Palliative Care Units/Hospices

  • Bathesda, Glengary, Hollywood, Kalamunda, Murdoch
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10
Q

How to communicate to palliative care patients?

A

Important to:

Be respectful of the situation

Develop rapport and trust

Reduce stress and anxiety

Convey important information

Be comfortable talking about:

– decision making & care planning care for deteriorating health

– dying

Allow time

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11
Q

What are some thical considerations for palliative care?

A
  • Most concerns centre around cause of death
  • Hydration and feeding
  • Cardiopulmonary resuscitation
  • Requests for assistance to die
  • Family concerned that medications causing deterioration
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12
Q

What does advance care planning mean?

A

Failure to talk about and plan for death is one of the msot significant obstacles to imprvoing the quality of dying

To meet our desire for better deaths

  • be informed about the limits of health care
  • importance of discussing our preferences for end-of-life care
  • the development and implementation of Advanced Health Directives
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13
Q

What are the common physical symptoms in palliative care?

A

Fatigue

Pain

Dyspnoea

Nausea and vomiting

Constipation

Anorexia

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14
Q

What are the common psychological symptoms?

A

Emotional Distress

Anxiety

Depression

Confusion

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15
Q

What should be asssessed before treating the previous symptoms?

A

Evaluation of

  • Contributing factors
  • Characteristics of the symptoms (intensity, location, quality, temporal nature, frequency, and associated pattern of disability)
  • The meaning of the symptom to the person (including beliefs about the symptom and the effect on the person’s physical, psychological, and social well-being)
  • Actions that the person is taking to manage or cope with the symptom
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16
Q

Effective symptom management typically requires?

> 3 types of approach

A

An integrated approach

  • multidimensional assessment and management

Target approach

  • directed at specific casual pmechanisms and factors contributuing to the problem

Tailored approach

  • suitable for individual circumstanses, beliefs and preferences
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17
Q

How is multimodal analgesia achieved in patients with palliative care needs? What are the medications used?

A

Multimodal analgesia = combined use of different classes of analgesics

Improve the effectiveness of pain relief

Reduction of dose of each analgesic medication and therefore intensity of any side effects

>anticonvulsants

>TCA

>distraction, relaxation, surgery, opioids, ketamine, massage, TENS, NSAIDS, corticosteroids, paracetamol

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18
Q

What are the general principles of pain relief?

A

By mouth

By the clock –> at fixed intervals

By the ladder

For the individual –> there are no standard doses of opioids

With attention to detail –> monitoring of effect and adverse effects

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19
Q

Wha is thhe WHO analgesic ladder?

A

Step 1 = non-opioids +/- adjuvants

Step 2 = weak opioids + non opioids +/- adjuvants

Step 3 = strong opioids + non-opioids +/- adjuvants

20
Q

Properties of opioids in palliative care?

A

Mainstay of analgesia in advanced illness

NOT saved as a last resort or when a person is near to death

No opioid is superior

Choice is based on individual patient factors

Low risk of the person becoming addicted when used in appropriate doses

21
Q

How to initiate opioids?

A

Start low and go slow

  • Consideration of specific patient factors

Start with imediate rlease, short acting opioids

  • Allows more flexiblity in titration
  • Results in faster tiration

Give on a regular basis, not prn

  • Maintenance of plasma levels
  • Waiting for pain to occur may exacerbate pain

Change to extended release for background

  • Ensure breaktthrough or rescue available
22
Q

What are examples of opioids available?

A

Buprenorphine

Codeine

Fentanyl

Hydromorphone

Methadone

Morphine

Oxycodone

Tapentadol

Tramadol

23
Q

What are the preferred opioids in palliative care?

A

Morphine and oxycodone

  • Familiarity, cost and availability
  • Wide range of oral formulations
  • Similar adverse effect profile

Different metabolism

  • glucoronidation vs CYP3A4 (morphine) and CYP2D6 (oxycodone)
  • nmorphine metaboilite potent
  • accumulation in renal dysfunction
24
Q

What are the other commonly prescirbed opiuoids?

A

Fentatnyl

  • patch and sublingual/buccal
  • if oral route not available or preferred
  • preferred in renal dysfunction

Hydromorphone

  • Potent
  • Oral and injectable formulations

Methadone

  • Specialist use only
  • Potent and complicated kinetics
25
Q

General principles of management of nausea and vomiting?

A

Assess likely cause •

Treat any reversible causes •

Use non-pharmacological measures such as:

  • avoidance of foods with strong tastes and smells
  • small and frequent meals – distraction techniques

Prescribe an anti-emetic depending on the aetiology

Review if necessary and make adjustments such as:

  • Up titration of dose –
  • Changing the route of administration –
  • Adding a second anti-emetic
26
Q

What are the common causes of nausea and vomiting in palliative care?

A

Gastric stasis

Medications

Intestinal obstruction

Raised intraocular pressure

Biochemical

Other

27
Q

What is the mechanism for nausea and vomitting?

A
28
Q

What are the neurotransmitters reponsible for nausea and vomitting? And what are the subsequent medications used to treat it?

A

Chemoreceptor trigger zone

  • NT: dopamine, serotonin
  • Medications: metoclopramide, haloperidol, prochlorperazine

Cortical

  • NT: GABA and serotonin
  • Medications: dexamethasone and BZDs

Vestibular

  • NT: histamine1, acetylcholine muscarinic
  • Medications: promethazine, prochlorperazine and cyclizine

Gastrointestinal

  • NT: dopamine, serotonin, acetylcholine muscarinic
  • Medications: metoclopramide, hyoscine, ondansetron

Vomiting centre

  • NT: acetylcholine muscarinic, histamine, serotonin
  • Medications: promethazine, cyclizine, hyoscine
29
Q

What are the first line antiemetics for palliative care patients?

>prokinetic (gastric stasis)

>chemoreceptor trigger zone (drugs, biochemical)

>vomiting centre (raised intracranial pressure, motion sickness)

A

Prokinetic (gastric stasis)

  • metoclopramide 10mg tds

Chemoreceptor trigger zone (drugs, biochemical)

  • haloperidol 0.5-2.5mg bd

Vomiting centre

  • raised intracranial pressure, motion sickness
  • promethazine 10-25mg bd
  • cyclizine 25-50mg tds
30
Q

How to mange dyspnoea?

A
  • distressing for patient and family
  • 70% cancer patients in last 6 weeks
  • cardiac disease, lung disease, renal disease
  • prevalence and severity increases closer to death
  • subjective and does not correlate to objective measures

dyspnoea: difficult or laboured breathing

31
Q

How to manage dyspnoea (non-pharm pls)?

A

Treat any reversible casues

Non-pharmacological mangement

  • reassurance
  • positioning
  • calm environment –> help with anxiety
  • windows open or fans blowing in face
32
Q

How to manage dyspnoea (pharm pls)?

A

Morphine is drug of choice for dyspnoea

  • oral or subcutaneous (not nebulised)
  • relieves sensation of dyspnoea
  • no detrimental effect on respiratory function
  • small doses usually effective

>1-2mg prn orally of morphine

  • dyspnoea is more severe in patients with unrelieved pain
33
Q

What are some other medications that may be used for dyspnoea?

A

Dyspnoea associated with anxiety

Adding BZD to morphine beneficial effect

>lorazepam 0.5-1mg sublingual bd prn

> midazolam 5-10mg/day via subcut infusion

34
Q

What are the reasons for constipation? What to do and what to avoid?

A

Very common symptom

>multiple reasons for constipation

  • decreased diet, fluids
  • disease state
  • medications

general good bowel hygiene

  • if possible fluids, exercise, dietary fibre

avoid osmotic or fibre products

  • if only eating and drinking minimum amounts
35
Q

What medications are used for constipation?

A

Stimulants with a softener

  • Coloxyl and Senna® 2 nocte – 3 bd
  • Coloxyl® 120mg 1-2 bd PLUS Bisalax® 10-20mg nocte OR Senokot® 4-6 nocte

Macrogol

  • e.g. Movicol®
  • isosmotic 1-6 sachets per day

Methylnaltrexone

  • peripheral opioid receptor antagonist
  • Indicated for opioid induced constipation
36
Q

What is terminal restlessness? What is the main cause? e

A

Delirium particular to the last days of life

  • Confusion, agitation, hallucinations

Incidence nearly 90%

Often multifactorial in palliative care patients

  • Main cause is often primary irreversible disease (s)
  • Other causes:

> decreasing renal and hepatic function, medications, hypoxia, dehydration, hypoglycaemia, infection or drug withdrawal

37
Q

Non-pharmacological management of terminal restlessness?

A

Less able to reverse causes

Aim to reduce harm to patient or family

Simple non-pharmacological management

  • Regular reorientation and reassurance
  • Familiar surrounds and carers, reduce distressing stimulation
  • Pain assessment and management
  • Correct dehydration, constipation and urinary retention
  • Oxygenation may be appropriate if hypoxia
  • Avoid physical restrain
38
Q

Pharmacological management of terminal restlesness? What to add if sedation required?

A

Management: •

  • haloperidol 0.5–1 mg subcut prn •
  • haloperidol 2.5-5 mg/day subcut infusion

If sedation required ADD:

  • clonazepam 0.2 mg subling prn –
  • clonazepam 0.5-1 mg/day subcut infusion –
  • midazolam 1 mg subcut prn –
  • midazolam 5-10mg /day subcut infusion
39
Q

what are the factors to consider when elderly take medications?

A

generally taking many medications

number of medications increases as health deteoriates

  • more for symptom management
  • secondary prevention medications continued
  • increased number high risk medications
  • anticholinergic load increased
40
Q

What is the criteria for assessing medications in terms of deprescribing?

A
  • Beers
  • Medication Appropriateness Index
  • Drug Burden Index
  • Anticholinergic Risk Scale
  • STOPP
41
Q

What are medication considerations?

A

Life epectancy

Goals of care

Time until benefit

Effects of continuing therapy –> risk-benefit ratio

Short term benefit (anything not going to work in weeks/months = uselss)

>survival

>quality of life

>symptom management

42
Q

What is the checklist of a newly diagnosed diabetic?

A
  • Cease smoking
  • Decrease weight
  • Increase exercise
  • Control BP
  • Treat dyslipidaemia
  • Antiplatelet
  • Blood glucose control

Aim to decrease complications

>macrovascular (CVD, stroke)

>microvascular (neuropathy, nephropathy, retinopathy)

43
Q

What are the advantages of using SC infusions (syringe drivers)

A
  • portable
  • less infection risk than IV
  • reliable absorption
  • filled on daily bassis
  • increased patient comfort
  • can be used easily at home
44
Q

What are the indications of SC infusions?

A

Unable to take oral medicatiosn because:

  • nausea and vomiting
  • dysphagia
  • severe weakness or unconscious
  • poor oral absorption due to dsease process
45
Q

What are SC injection sites?

A

Scapular region

Anterior chest wall

Anterior aspect of thighs

Anterior aspect of upper arms

Anterior abdominal wall

46
Q

What are some medications infused subcutaneously?

A

Common medications

  • Analgesics

> morphine, hydromorphone

  • Antiemetics

> metoclopramide, haloperidol, promethazine

  • Sedatives

> clonazepam, midazolam

  • Others

> hyoscine butylbromide, glycopyrronium (glycopyrrolate)