Module 4.3 (Urinary Incontinence) Flashcards

1
Q

Define the following terms:

A) Urinary incontience/enuresis

B) Nocturnal enuresis

C) Urgency

D) Nocturia

E) Increased daytime frequency

F) Retention

A

A)

  • The complaint of any involuntary leakage of urine

B)

  • Any involuntary loss of urine during sleep

C)

  • The complaint of a sudden, compelling desire to pass urine, which is difficult to defer
  • Urgency can be with/without incontinence

D)

  • The complaint that the individual has to wake at night one or more times ot void

E)

  • The complaint by the patient who considers that he/she voids too often by day

F)

  • Inability to urinate
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2
Q

What is meant by continene?

A

A normal bladder

  • empties 4-8 times each day (every 3-4 hours)
  • can hold up to 400-600ml of urine (the sensation of needing to empty occurs at 200-300 ml)
  • may cause nocturnal awakening once at night to pass urine (twice if over 65 years of age)
  • Tells a person when it is full but gives them enough time to find a toilet
  • Empties completely each time urine is passed
  • Does not leak urine
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3
Q

What does untreated UI heighten the risk of?

A
  • Infection
  • Pressure ulcers –> skin infections
  • Social isolation and depression
  • Loss of sleep
  • De-conditioning
  • Falls and associated fractures
  • Nursing home admission
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4
Q

What is the physiology the bladder?

A

When want to fill ballder = cholinergic nerves turned off and beta adrenergic system turned on. If beta adrenergic system turned on = sphincter will constrict.

When want to urinate = cholinergic nerves turned on and beta adrenergic system turned off. Cholinergic nerves turned = detrusor contracting and push urine out of the bladder and into the urethra.

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5
Q

What are the basic requirements for continence?

A

Bladder – relaxed while filling, contracts to empty ◼

Sphincter mechanism – prevents leakage and relaxes to urinate ◼

Pelvic floor – supports the bladder and aids the sphincter ◼

Nervous system – transmits messages to/from brain ◼

Brain – interprets messages and sends commands ◼

Locomotor ability – to get to and use the toilet

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6
Q

What does urine storage require?

A

Accommodation of increasing volumes of urine at a low intravesical pressure (normal compliance) and with appropriate sensation.

A bladder outlet that is closed at rest and remains so during increases in intra- abdominal pressure.

Absence of involuntary bladder contractions (detrusor overactivity).

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7
Q

Bladder emptying/voiding requires?

A

A coordinated contraction of the bladder smooth musculature of adequate magnitude and duration.

A concomitant lowering of resistance at the level of the smooth and striated sphincter.

Absence of anatomic (as opposed to functional) obstruction.

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8
Q

What are some risk factors for urinary incontinence?

A

Women

  • Pregnancy
  • Child birth
  • Menopause
  • Pelvic Surgery

Men

  • Benign prostatic hyperplasia
  • Prostate surgery

Non gender-specific

  • Smoking
  • Obseity
  • Recurrent urinary tract infections
  • Reduced mobility
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9
Q

What the medical conditions asscociated with UI?

A

◼ Stroke ◼ Parkinson’s disease ◼ Dementia◼ Sleep apnoea ◼ Depression ◼ Behavioural disorders ◼ Diabetes (polyuria, polydipsia, neuropathy) ◼ Congestive heart failure

CHF: produce more urine at night time because renal perfusion is better at this time = increased risk of nocturnal enuresis

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10
Q

What are the types of UI?

A

Stress urinary incontinence

  • Involuntary leakage on effort, exertion, sneezing or coughing

Urge urinary incontinence

  • Involuntary leakage immediately preceded by urgency

Overflow urinary incontinence

  • Also referred to as “chronic retention of urine”
  • Emptying failure by outlet obstruction or inability to contract detrusor

Functional incontinence

  • Lack of recognition or ability to get to toilet in time - unrelated to bladder and nervous control

Mixed incontinence

  • Combinations of the above
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11
Q

General management principles for UI?

A
  • Decrease intake of fluids, caffeine, and carbonated drinks
  • Constipation should be managed and avoided
  • Lose weight if BMI >25kg/m2
  • Urodynamic studies
  • UTI investigations
  • Bladder diary

> Number of pads needed over 24 hrs and their type

> Activity restriction

> Frequency of accidents

> Record of symptoms – presence, frequency, severity

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12
Q

The most common type of incontinence amongst young and middle-aged women? Caused by?

A

Stress Incontinence

Caused by:

  • Childbirth, pelvic surgery (eg prostatectomy), or an abnormal position of the urethra or uterus
  • Lack of oestrogen in postmenopausal women
  • Obesity
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13
Q

What medications to cease for stress incontinence?

A

alpha-adrenergic blockers becuse it relaxes the sphincter

systemic oestrogen

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14
Q

What to use for stress incontinence?

A

Topical oestrogens = thicken up mucus membranes and strengthen sphincter

Duloxetine (5HT and NA) –> 5HT and NA causes sphincter to constrict

A-adrenergic agonists = not used much

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15
Q

How to manage stress incontinence?

A

Pelvic floor exercises ◼ Treat chronic cough ◼ Treat constipation/ faecal impaction ◼ Weight reduction ◼ Surgery ◼ Vaginal pessaries (nonmedicated)

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16
Q

When should pelvic floor muscle training be used (PFMT)

A

Should be offered to all women with SUI and UUI (urge urinary incontinence) as first-line management

> most effective for stress urinary incontinence

Women treated with PFMT more likely to report improved or cured UI

>Also report fewer incontinence episodes per day and a better quality of life

Must contract correct pelvic muscles to be effective

> may require more than verbal and written isntructions

17
Q

SNRIs for UI?

A

Duloxetine may reduce the frequency of episodes of incontinence and improve quality of life scores

Generally not curative

Nausea common, but does not commonly cause discontinuation

18
Q

What are examples of adrenergic agonists? Are they used?

A

D-adrenergic agonists - phenylpropanolamine, midodrine

Side effects common

  • insomnia, restlessness and vasomotor stimulation
  • cardiac arrhythmias and hypertension have been reported but are rare

Almost never used in australia

19
Q

what is urge continence? what are the causes?

A

Urine loss, accompanied by or immediately preceded by urgency (sudden compelling desire to pass urine which is difficult to defer)

Commonest in elderly, often in combination

Causes

  • Neurological conditions e.g. Parkinson’s, MS, Alzheimer’s, CVA
  • Constipation
  • Enlarged prostate
  • UTIs
20
Q

What is an overactive bladder? What are the types?

A

Symptom syndrome suggestive of lower urinary tract dysfunction

  • Urgency, with or without urge incontinence
  • Usually with frequency and nocturia
  • Also called overactive bladder syndrome, urge syndrome, urgency-frequency syndrome (previously detrusor instability)

OAB wet –> urge with loss of urine

OAB dry –> urge without incontinence

21
Q

How to manage urge incontinence?

A

Exclude UTI

Treat constipation/ faecal impaction ◼ R

educe caffeine and alcohol intake ◼

Limit fluid intake ◼

Bladder training ◼

Pelvic floor exercises

Medications

  • anticholinergic or tricyclic antidepressant ◼
  • mirabegron ◼
  • Botulinum toxin (BotoxTM) ◼
  • E-adrenergic agonists (terbutaline)
22
Q

What anticholnergics/TCA are used for urge incontinence?

A

cautious using in elderly, cognitive AE = confused, delirious, forgetful

Imipramine (Tofranil) ◼ and other TCAs ◼ Dicyclomine (Merbentyl) ◼ Propantheline (Pro- Banthine) ◼

Specific for urinary function:

Oxybutynin (Ditropan, Oxytrol) ◼ Darifenacin (Enablex) ◼ Tolterodine (Detrusitol) ◼ Solifenacin (Vesicare)

23
Q

Discuss anticholinergics in overactive bladder?

A

Benefit varies between individuals

  • on average there is one fewer episode of incontinence per 48 hours compared with placebo

No evidence of superior efficacy with newer agents (eg solifenacin, darifenacin) compared to oxybutynin

  • Newer agents potentially better tolerated

Monitor for adverse effects (including changes in cognitive function) and assess for improvement in symptoms

  • Stop after 4 weeks if there is no overall benefit
24
Q

When is botox an option?

A

Onabotulinumtoxin-A is an option for people who cannot use, or do not adequately respond to, anticholinergics

Injected into the detrusor every few months

Patients must be willing to perform self-catheterisation if necessary

25
Q

How does mirabegron work?

A

Beta3-adrenoceptor agonist

  • relaxes bladder muscle during the storage phase of micturition, increasing bladder capacity

May increase BP and heart rate; avoid use in severe, uncontrolled hypertension

Sinilar effectiveness to anticholinergics

26
Q

What is overflow incontinence?

A

due to urinary retention or underactive bladder

outfow blockage

  • enlarged prostate
  • constipation

symptoms

  • frequency, urgency, nocturia
  • incomplete bladder emptying
  • frequent UTIs
27
Q

How to manage overflow incontinence?

A

Cease anticholinergics

Try

  • ◼ D-adrenergic antagonists –> prazoisn, terazosin, tamsulosin (relax sphincter and urethra as much as possible to mininise outflow obstruction)
  • 5 alpha reductase inhibitors (shrink prostate)

> finasteride, dutasteride

> saw plametto

  • catherisation
  • srugery
28
Q

When to give alpha blockers? How do they help? When not to give?

A

a-adrenergic antagonists

  • Alfuzosin
  • Prazosin
  • Terazosin
  • Tamsulosin

Block receptor in bladder neck and urethra, which may help to reduce outflow obstruction and overflow incontinence in males –> may precipitate or worsen incontinence in women

dont give in stress incontinence = urethra and sphincter need to be closed and may worsen it in women

29
Q

What is functional incontinence? Treatment?

A

Loss of urine due to inability/unwillingness to go to a toilet

Associated with

  • Immobility (stroke, arthritis)
  • Loss of mental function eg AD

Treatment

  • Regular toileting assistance
  • Try to avoid reliance on garments/pads
30
Q

Key messages?

A

Urinary incontinence is common and treatable

Medications can improve or worsen urinary incontinence

> Ensure medications are reviewed when incontinence presents or worsens

> Review effectiveness of medications used for continence