Module 4 lec 3

Question 1

what interactions can xenobiotics have with the immune system?

Answer 1

Immunosuppression (decreased response)
immuno-stimulation (increased response)
hypersensitivity (affect B or T cells)
autoimmunity (antibodies target body)

Question 2

what are the 4 hypersensitivity reactions?

Answer 2

immediate
antibody-mediated
immune complex mediated
cell-mediated

Question 3

explain immediate hypersensitivity process

Answer 3

first exposure has no harmful effects
antibodies are made for the future
future exposures attach to antibody and elicits effects

Question 4

explain anti-body mediated hypersensitivity process

Answer 4

chemical attaches to body cell, antibodies attach to chemical, body attacks both cell and chemical
produces inflammation

Question 5

explain immune complex-mediated hypersensitivity process

Answer 5

antigen and antibody attach to cell linings (called a complex)
complex grows / accumulates
complement system begins attaching to complexes

Question 6

explain cell-mediated hypersensitivity process

Answer 6

macrophage takes sample of chemical to T cell
T cell releases cytokines
more macrophages are recruited