Module 3.2.2: Drugs Used in Heart Failure Flashcards
Occurs when cardiac output is inadequate to provide oxygen needed by the body.
It is a progressive disease that is characterize by a gradual reduction in cardiac performance, punctuated in many cases by episodes of acute decompensation
Most common cause: coronary artery disease.
Heart failure
o reduced cardiac output.
o reduced ejection rate fraction (
Systolic failure
o A result of hypertrophy and stiffening and loss of adequate relaxation of the myocardium.
o Cardiac output is reduced.
o Ejection fraction may be normal.
o Does not usually respond optimally to positive inotropic drugs.
o Proportion of patients increase with age.
o Stroke volume is significantly decreased.
Diastolic failure
o Result from hyperthyroidism, beriberi, anemia, and arteriovenous shunts.
o Treated by correcting the underlying cause.
Manifestations: o Heart failure tachycardia o Decreased exercise tolerance o Shortness of breath o Peripheral and pulmonary edema o Cardiomegaly o Rare form of heart failure. o Demands of the body are so great that even an increase in cardiac output is insufficient.
High-output failure
______ helpful mainly in acute systolic failure and also reduces symptoms in chronic systolic heart failure.
Positive inotropic drugs
o A sodium pump and the site of action of cardiac glycosides.
o The major determinant of sodium oncentration in the cell.
o The primary target of Digoxin and other cardiac glycosides.
Na+/K+-ATPase
o A sodium-calcium exchanger.
o Uses the sodium gradient to move calcium against its concentration gradient from the cytoplasm to the extra-cellular space.
NCX
o A voltage-gated, L-type calcium channel.
Cav-L
o A calcium transporter ATPase that pumps calcium into the sarcoplasmic reticulum (SR).
o Maintains free cytoplasmic calcium at very low levels during diastole by pumping calcium into the SR.
SERCA (sarcoplasmic endoplasmic reticulum Ca2+ -ATPase)
SERCA is inhibited by _______; phosphorylation of _______ by protein kinase A (eg, by βagonists) removes this inhibition.
phospholamban
A calcium bound to calsequestrin, a high-capacity Ca2+-binding protein.
CalS
A calcium-activated calcium channel in the membrane of the SR that is triggered to release stored calcium.
RyR (ryanodine RyR2 receptor)
Acts at the actin-troponin-tropomyosin complex where activator calcium brings about the contractile interaction of actin and myosin.
Calcium sensitizers
_____ increases calcium sensitivity, inhibits phosphodiesterase, and reduces symptoms of heart failure.
Levosimedan
Neurohumoral or extrinsic compensation involves two major mechanisms:
o Sympathetic Nervous System
o Renin-Angiotensin-Aldosterone Hormonal Response
The most important intrinsic compensatory mechanism is ______.
myocardial hypertrophy
the term applied to dilation (other than that due to passive stretch) and other slow structural changes that occur in the stressed myocardium. It may include proliferation of connective tissue cells as well as abnormal myocardial cells with some bio-chemical characteristics of fetal myocytes.
Remodeling
o Failure is associated with no limitations on ordinary activities
o Symptomatic only with greater than ordinary activity (severe exercise.
HEART FAILURE: Class I
o Slight limitation of ordinary activities
o Fatigue and palpitations with ordinary physical activity.
HEART FAILURE: Class II
o Failure results in no symptoms at rest.
o Fatigue, shortness of breath, and tachycardia occur with less than ordinary physical activity.
HEART FAILURE: Class III
o Associated with symptoms even when the patient is at rest.
HEART FAILURE: Class IV
______ patients are at high risk because of other disease but have no signs or symptoms of heart failure.
Treatment of patients at high risk should be focused on control of hypertension, hyperlipidemia, and diabetes, if present.
Stage A
______ patients have evidence of structural heart disease but no symptoms of heart failure.
Treatment of patients at high risk should be focused on control of hypertension, hyperlipidemia, and diabetes, if present.
Stage B
______ patients have structural heart disease and symptoms of failure, and symptoms are responsive to ordinary therapy.
Active treatment must be initiated.
Stage C