Module 3 Part A/B Flashcards
Describe physiologic respiratory changes that occur during the PP period
Removal of pregnancy weight allows for immediate relief of intra-abdominal pressure that allows for elevation of the diaphragm and resolution of shortness of breath. Tidal volume returns to normal.
Describe physiologic renal system changes that occur during the PP period.
There is a gradual return to nonpregnant GFR, renal plasma flow, plasma creatinine, BUN and creatinine clearance. Mild proteinura may develop. Natriuesis and diuresis occur over the 3 weeks PP returning to prepregnant blood volume level. Blader tone, size and function returns to normal over 6-8 weeks
Describe physiologic hepatic system changes that occur during the PP period.
LFTs return to normal levels by 3 weeks PP, Alkaline phosphate returns to normal within 6 weeks.
What PP changes should patients expect concerning the following hyperpigmentation pregnancy-related skin changes? Ex: Linea nigra, melasma, Areola, Striae gravidarum (stretch marks)
Skin changes will gradually fade or regress over 6 months PP. Many do not completely disappear. Ex. striae will turn while in 3 months.
Describe PP changes for the following hormones:
Thyroid-binding globulin, triiodothyronine (T3) and thyroxine (T4) levels
Decreasing estrogen causes a drop in T3 and T4 with a gradual return to prepregnant level. PP thyroid dysfunction is typically transient
Describe PP changes for the following hormones: Placental hormones human placental lactogen (hPL), human chorionic gonadotropin (hCG), estrogen, and progesterone
There is abrupt drop in estrogen, progesterone, hcg, and hcl when the placenta is expelled.
Describe PP changes for the following hormones:
Pituitary function, gonadotropin-releasing hormone )GnRH), FSH, and LH in nonlactating and lactating women
Following birth, FSH and LH levels remain low for the first 2 postpartum weeks, but then rise gradually. Ovarian production of estrogen and progesterone, therefore, also remains low during the first few postpartum weeks. In nonlactating PP patients, ovulation can return within 1-3 months.
Outline the major hemodynamic changes that occur in the first few hours of the puerperium that would explain changes in cardiac output, bradycardia, and orthostatic hypotension.
Blood loss at birth causes a decrease in RBC volume and hemodilution. The significant blood loss and autotransfusion causes an 80% increase in cardiac output and stoke volume. Blood volume returns to prepregnant levels by 2 weeks PP.
Describe the hemostatic actions that occur within the uterus to minimize blood loss during the postpartum period. How do these relate to afterpains? What role do changes in clotting factors play?
Mobilization of extracellular fluid back into circulation in the first few postpartum days also contributes to increased maternal blood volume. This acute increase in blood volume helps compensate for the normal blood loss of parturition.
Outline the steps in the regeneration of the endometrium, in both the nonplacental and placental areas, giving the time frame
Myometrial cells shrink/autolyse and the uterus is involuted by 50% in 24-48 hours then gradually diminished over 6-8 weeks. Myometrial cells decrease in size**
Describe the reorganization of the myometrium.
Describe expected fundal height changes over the first two weeks of the puerperium.
The fundus lowers by one fingerbreadth or 1 cm every day. After 14 days PP, the fundus is no longer palpable in the abdomen
Consider other reasons why uterine involution may occur more slowly.
Overextended uterus due to fibroids, multiple pregnancy, miltiparas, retained placenta, clots, endometritis
Compare and briefly explain (normal vs. abnormal) the values you would expect to see in the late prenatal period with those of the first or second day postpartum for the following lab: Hgb/Hct
A hemoglobin (Hgb) drop of 1 g = 500 mL
A hematocrit (Hct) drop of 1% = 250 mL
Compare and briefly explain (normal vs. abnormal) the values you would expect to see in the late prenatal period with those of the first or second day postpartum for the following lab: WBC
WBCs are elevated in labor and gradually return to normal in the puerperium.
Compare and briefly explain (normal vs. abnormal) the values you would expect to see in the late prenatal period with those of the first or second day postpartum for the following lab: plts
Normalizes by 12 weeks PP
Compare and briefly explain (normal vs. abnormal) the values you would expect to see in the late prenatal period with those of the first or second day postpartum for the following lab: Urinary protein
Mild proteinuria may develop in the first few postpartum days. Will return to prepregnant status in 2-3 days
According to the journal’s article on Management of PP Pain, how does estrogen, oxytocin, and perception of the birth experience affect pain sensitivity?
Preclinical studies (using animal models) have demonstrated that estrogen, which is markedly elevated during pregnancy, heightens pain sensitivity through both peripheral and central
mechanisms. Estrogen declines rapidly postpartum following the birth of the placenta, and thus a reduction in pain sensitivity may occur with its decline. Elevated oxytocin levels in the puerperium and while breastfeeding may partially account for the low incidence of persistent, chronic pain even after surgical childbirth.
What are potential causes of pain during the postpartum period?
Perineal tear/episiotomy, C/S pain, afterpain, breast pain, hemorrhoids
How does the degree of perineal trauma affect perineal pain following birth?
Perineal pain is experienced in some women even if they have an intact perineum, with the severity usually related to the degree of tissue trauma.
Describe dosages, administration routes, frequency, adverse effects, maximum dose/day, and breastfeeding safety for the following pain medication: Acetaminophen
Inhibits cox-3, can get 325-650 every 4-6 hours for a max of 4gm in 24 hours due to risk of liver toxicity. There is a risk of overdose due to combination products. Tylenol is considered safe with BF.
Describe dosages, administration routes, frequency, adverse effects, maximum dose/day, and breastfeeding safety for the following pain medication: Ibuprofen
Ibuprofen is a true NSAID. It can be given 400-800 mg every 4-6 hours With a max of 2.4g in 24 hours for pain and 3.6 g in 24 hours for fever. This works well for pain and inflammation and is considered safe for BF.
Describe dosages, administration routes, frequency, adverse effects, maximum dose/day, and breastfeeding safety for the following pain medication: Toradol
Toradol is an IV NSAID and very similar to ibuprofen slide
Describe dosages, administration routes, frequency, adverse effects, maximum dose/day, and breastfeeding safety for the following pain medication: Acetaminophen/Codeine No. 3
The risk with Tylenol 3 is for those that are ultra-rapid metabolizers. There has been a neonatal demise due to OD of a baby of opioids through breastmilk of an ultra-rapid metabolizer