Module 3: Mechanisms of Normal Hemostasis Flashcards
1
Q
Factor I common name
A
Fibrinogen
2
Q
Factor II common name
A
Prothrombin
3
Q
Factor IIa common name
A
Thrombin
4
Q
Factor III common name
A
Tissue factor
5
Q
Factor V common name
A
Labile factor
6
Q
Factor VII common name
A
Stable factor
7
Q
Factor VIII common name
A
Antihemophilic factor
8
Q
Factor IX common name
A
Christmas factor
9
Q
Factor X common name
A
Stuart-Prower factor
10
Q
Factor XI common name
A
PTA (plasma thromboplastin antecedent)
11
Q
Factor XII common name
A
Hageman factor
12
Q
Factor XIII common name
A
Fibrinase
13
Q
Fibrinogen roman numeral
A
I
14
Q
Prothrombin roman numeral
A
II
15
Q
Thrombin roman numeral
A
IIa
16
Q
Tissue factor roman numeral
A
III
17
Q
Labile factor roman numeral
A
V
18
Q
Stable factor roman numeral
A
VII
19
Q
Antihemophilic factor roman numeral
A
VIII
20
Q
Christmas factor roman numeral
A
IX
21
Q
Stuart-Prower factor roman numeral
A
X
22
Q
PTA (plasma thromboplastin antecedent) roman numeral
A
XI
23
Q
Hageman factor roman numeral
A
XII
24
Q
Fibrinase roman numeral
A
XIII
25
5 major components of hemostasis
```
Vascular
Platelet
Coagulation system
Fibrinolytic system
Natural anticoagulants and inhibitors
```
26
Vascular endothelial cells are thromboresistant by secreting:
Heparin sulphate
Prostacyclin (prostaglandin)
Nitrous oxide
27
How does heparin sulphate contribute to thromboresistance?
Inhibits coagulation
28
How does prostacyclin contribute to thromboresistance?
Inhibits platelet adhesion and aggregation
29
How does nitrous oxide contribute to thromboresistance?
Relaxes smooth muscles in subendothelial area and prevents vasoconstriction
30
2 types of vasoconstriction
Muscular
| Humoral
31
Tissue thromboplastin acts as a coenzyme with factor VII to activate:
Extrinsic coagulation
32
Tissue plasminogen activator (tPA) activates:
The fibrinolytic system
33
3 tests for vascular responses:
Bleeding time
Closure test
Capillary fragility test
34
Endothelin is:
Secreted by endothelial cells
| Induces smooth muscle contraction in surrounding subendothelial tissue
35
Damaged vessels or injured cells release/expose:
```
Tissue thromboplastin (factor III)
Tissue plasminogen activator (tPA)
```
36
Thrombopoiesis differs from other blood cells by:
Megakaryocytes get larger as they mature
| No cellular division; endomitosis (repeated nuclear divisions) within developing cells
37
Platelet lifespan in the blood:
8-10 days
38
Peripheral zone of platelet
Outer coating = glycocalyx (mostly glycoprotein)
| Important in adhesion and aggregation
39
Sol-gel zone of platelet
Cytoskeleton (contractile proteins - thrombosthenin and actinomysin)
Platelet retraction, shape change (viscous metamorphosis in secondary aggregation)
40
Organelle zone of platelet
Canicular system
Dense bodies
Alpha (translucent) granules
Dense tubular system
41
Canicular system
Carries granular contents to the surface
42
Dense bodies
Rich in serotonin and other vasoactive catecholamines, ADP, ATP, calcium, pyrophosphate
43
Alpha (translucent) granules
PF3, fibrinogen, thrombospondin, PF4
44
Dense tubular system
Calcium
| Important in platelet retraction and prostaglandin synthesis
45
% of platelets in circulation
70%
46
% of platelets sequestered in the spleen
17%
47
% of platelets in liver, lungs, and bone marrow
13%
48
PF1 is:
Absorbed coagulation factor V
49
PF2 is:
Fibrinogen activating factor
50
PF3 is:
Platelet phospholipid
51
PF4 is:
Anti-heparin factor
52
2 platelet function groups
Hemostatic
| Thromboplastic
53
Platelet adhesion requires:
Glycoprotein 1b complex (GP1b)
| von Willebrand's factor (VWF) - part of factor VIII complex
54
2 platelet aggregation phases
Primary (reversible)
| Secondary (irreversible)
55
Primary aggregation requires:
ADP
Glycoprotein IIb/IIIa complex
Calcium
Fibrinogen (factor I)
56
The contractile protein involved in platelet retraction is:
Thrombosthenin
57
Cheating agents inhibit platelet aggregation by:
Removing calcium (essential for secondly aggregation)
58
Heparin inhibits:
Thrombin
59
Aspirin inhibits platelet aggregation by:
Inhibiting thromboxane A2 synthesis in platelets
60
Factor V is a coenzyme for factor:
X
61
Factor VIII is a coenzyme for factor:
IX
62
HMWK is a coenzyme for factor:
XII
63
Factor III is a coenzyme for factor:
VII
64
Factor VIII is made up of which two components
Antihemophilic factor
| von Willebrand's factor
65
Contact group:
HMWK, PK, XI (PTA), XII (Hageman factor)
| His private parts hurt
66
Prothrombin group
II, VII, IX, X
Prothrombin, stable, Christmas, Stuart-Prower
Presents save Christmas Santa
67
Fibrinogen group
I, V, VIII, XIII
Fibrinogen, labile, antihemophilic, fibrinase
Fancy ladies acquire funds
68
Intrinsic system factors
HMWK, PK, XII, XI, IX, VIII
69
Extrinsic system factors
VII, III
70
Common pathway factors
X, V, II, I, XIII, IV
71
PT measures factors:
VII, X, V, II, I
Stable, Stuart-Prower, Labile, prothrombin, fibrinogen
Silly sluts love pillow fights
72
APTT measures factors:
HMWK, I, PK, XII, IX, VIII, X, V, II, XI
HMWK, PK, Hageman, Christmas, Antihemophilic, Stuart-Prower, labile, fibrinogen, prothrombin, PTA
Horny prostitutes have coitus and spread legs for precious pennies
73
Prothrombin is activated into thrombin by:
Xa, Va, PF3, Ca2+
74
Thrombin's major functions are
Converts fibrinogen into fibrin
Activates factor XIII
Enhances activity of factors V and VIII
Induces platelet aggregation
