Module 3: Market Landscape

Question 1

What ages are transdermal gels indicated for?

Answer 1

17 years of age and over

Question 2

Testosterone injections of __________ are given IM?

Answer 2

Aveed

Question 3

What are some AE’s of Testopel?

Answer 3

Implantation site infection

Question 4

What is the primary endpoint of most TRT drugs?

Answer 4

Percent of patients achieving total T within the normal range.

Question 5

Are there any TRT products indicated for age related HG?

Answer 5

No

Question 6

What are the 3 oral products?

Answer 6

Kyzatrex, Tlando, Jatenzo

Question 7

Which testosterone injection is administered SQ?

Answer 7

Xyosted

Question 8

Where should Xyosted be injected?

Answer 8

Abdominal region

Question 9

What contraindications are shared between Aveed and Xyosted?

Answer 9

Women who are pregnant.

Men with any hypersensitivity to any of the ingredients.

Men with carcinoma of the breast, or known, or suspected carcinoma of the prostate.

Question 10

Aveed has a boxed warning for?

Answer 10

POME (pulmonary oil microembolism.)

Question 11

All transdermal gels have a boxed warning for which?

Answer 11

Secondary exposure to testosterone.

Question 12

Which warnings and precautions are shared between all transdermal gels?

Answer 12

Abuse of T, CV risk, Polycythemia, worsening of BPH and potential risk for prostate cancer, VTE (venous thromboembolism), Hepatic AE’s.

Question 13

What was the most common AE when using a transdermal gel?

Answer 13

Application site/skin reaction

Question 14

What percentage of Androgel patients ahieved average serum testosterone concentration within normal range by day 180?

Answer 14

87%

Question 15

What AE is shared between Tlando and Kyzatrex?

Answer 15

Hypertension

Question 16

What % of patients met the primary efficacy endpoint in the Tlando trial? (mean serum testosterone concentrations in normal range at 24 days?)

Answer 16

80%

Question 17

What dose strengths are available with Kzatrex?

Answer 17

100mg, 150mg and 200mg

Question 18

What dose strengths are available with Tlando?

Answer 18

112.5mg

Question 19

How many mg are in each Testopel pellet?

Answer 19

75mg

Question 20

What is the recommended starting dose of Testopel?

Answer 20

150mg to 450mg every 3-6 months.

Question 21

How is Testopel administered?

Answer 21

SQ implant

Question 22

Which AE’s are specific to Natesto and not other TRT’s?

Answer 22

Nasal discomfort, nasal scabbing and sinusitis

Question 23

Natesto has a boxed warning for?

Answer 23

Natesto has NO boxed warning.

Question 24

How many times per day should Natesto be administered?

Answer 24

3