module 3 Flashcards

1
Q

what is a clinical prediction rule

A

a tool that contains the best combo if individual components of history, physical examination, and or lab test that can help a clinicion make a diagnosis and prognosis or select a approciate treatment

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2
Q

what do CPRs do

A

help a clinician make a diagnosis and prognosis or select an appropriate treatment

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3
Q

what is a diagnostic CPR

A

ID patient with a disorder

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4
Q

example of a diagnostic CPR

A

Ottawa ankle rules

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5
Q

treatment classification CPR

A

ID pt that would respond most favorable to a treatment

EX: lumbar spine manipulations

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6
Q

what are the steps n developing a CPR

A
  1. derivation
  2. validation
  3. impact analysis
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7
Q

what is derivation

A

ID predictors and create a rule

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8
Q

what is Validation

A

apply the rule in seperate independent samples

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9
Q

what is the impact analysis

A

assess how the rule impacts clinical outcomes and behavior

and or reduce costs

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10
Q

what is a narrow validation

A

application of the rule in a smilar clinical setting and population as the derivation stage

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11
Q

what is a broad valdiation

A

application of the rule in multiple clincial settings with varying prevelence and outcomes of the disease

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12
Q

approiate study designs for CPRs - prospective cohort studies

A

diagnostic/prognostic CPRs

treatment based CPRs in the derivation stage

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13
Q

what kind of study is also appropiate for diagnostic CPRs

A

cross sectional studies

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14
Q

approiate study designs for CPRs - RCT

A

treatment based CPR in the validation stage

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15
Q

what does operationally defined mean - target population

A

clearly articulated the inclusion and exclusion criteria

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16
Q

what can you assume if if a CPR survies validations

A

CPR is valid in predicting the outcome of interest

impact of the CRP clinician decision making

17
Q

how to choose predictor factors for a CPR

A

ID varible that predict and outcome by itself

ID a verible that when grouped with other outcomes increases the likelihood of the outcome together

18
Q

what do you use to see if predictor values work well together

A

multivariable regression analysis

19
Q

how do you know if the sample size was large enough

A

look for the sample size and or power in the discussion of the paper

20
Q

how should the outcome of interest be applied for CPRs

A

the tester should be trained on how to preform it

have objective criteria on positive and negative results

21
Q

what is attrition

A

the loss of study units from a sample.

when a study loses a subject and they are therefore not included in the analysis

22
Q

what level of attriction do you start to question the studies valdity

23
Q

in the valdiation stage what must the prediction rule be compared to

A

an established criterion (gold standard) or outcome of interest

24
Q

during the validation stage what must be true of the subjects

A

must be a second in-pendent group of subjects

25
what is the relationship between the criterion and the CPR
they must be perform independently
26
what cuase a study to fail the validation stage
the rule was inadquatly developed drastic difference in development population and validation pop bad sample size or power to detect effects
27
what stage are most CPR for PT
derivation stage many fail the validation stage almost none have undergone a impact anaylsis
28