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Phlebotomy Lecture Finals > Module 3 > Flashcards

Module 3 Flashcards

1
Q

Factor I

A

Fibrinogen

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2
Q

Factor lll

A

Tissue Factor

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3
Q

Blood clot that forms in a large vein in the leg

A

Deep venous thrombosis

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4
Q

Pathological, widespread clotting and fibrinolysis at the same time, in which coagulation factors are consumed to such an extent that bleeding occurs

A

Disseminated intravascular coagulation (DIC)

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5
Q

Genetic disorder characterized by bleeding due to increased coagulation time

A

Hemophilia

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6
Q

Hemophilia A is also known as

A

Factor Vlll deficiency

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7
Q

Hemophilia B is also called as

A

Factor IX

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8
Q

Abnormal decrease in platelets

A

Thrombocytopenia

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9
Q

What are the tests for hemostatic process?

A

D-dimer
Factor Assays
Fibrin degradation products(FDP)
Platelet function assay (PFA)
Prothrombin time (PT)
Partial thromboplastin time(PTT / APTT)

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10
Q

What is the first coagulation disorder to be recognized during second century?

A

Hemophilia

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11
Q

A chronic, malignant disorder, common in males characterized by lymph node enlargement

A

Hodgkin disease

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12
Q

an infection of the lymphatic system caused by Epstein-Barr virus

A

Infectious mononucleosis

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13
Q

Infectious mononucleosis is caused by

A

Epstein-barr virus

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14
Q

Inflammation of the lymph vessels

A

Lymphangitis

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15
Q

Inflammation of one or more lymph nodes

A

Lymphadenitis

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16
Q

Disease of the lymph nodes, often associated with node enlargement such as seen in mononucleosis

A

Lymphadenopathy

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17
Q

Sometimes benign but usually malignant

A

Lymphoma

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18
Q

Term for lymphoid tumor

A

Lymphoma

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19
Q

Spleen enlargement

A

Splenomegaly

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20
Q

What are the tests for lymphatic system disorders?

A

Bone marrow biopsy
Complete blood count (CBC)
Lymph node buopsy
Mononucleosis (mono) test

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21
Q

Where is axillary lymph nodes located?

A

Nodes in the armpit

22
Q

The process by which fibrin is dissolved

A

Fibrinolysis

23
Q

What are the two activities of fibrinolysis?

A

Dissolves clots (thrombi) that form within intact vessels

Removes hemostatic clots from tissue as healing occurs

24
Q

What substance converts plasmin?

A

Plasminogen

25
Q

An enzyme that breaks down fibrin into smaller fragments called the degradation products

A

Plasmin

26
Q

What do fibrin splits?

A

Products and D-dimer

27
Q

Bleeding is associated with

A

Increased fibrinolytic activity

28
Q

Thrombosis is associated with

A

Decrease fibrinolytic activity

29
Q

What does the liver synthesize/s in hemostasis?

A

Factor V
Factor Vlll
Prothrombin
Fibrinogen

30
Q

Who produce heparin naturally in the body?

A

Mast cells (tissue basophils) in the liver

31
Q

What happens when liver is diseased?

A

Bleeding may result

32
Q

Liver produces bile salts for

A

Absorption of Vitamin K

33
Q

Vitamin K deficiency can result to

A

Elevated PT and APTT, and potential bleeding

34
Q

Used for treating clotting disorders

A

Coumarins (coumadin and other warfarin trade names)

35
Q

How does coumarin works?

A

By inhibiting the proper synthesis of the vitamin-K dependent factors

36
Q

What are the three natural inhibitor?

A

Antithrombin (AT)
Heparin cofactor ll (HCll)
Proteins C and S

37
Q

Developed to inactivate thrombin inside a clot and prevent clot propagation with clotting disorders, such as deep venous thrombosis

A

Drug fondaparinux sodium (Arixtra)

38
Q

It is developed because antithrombin is too large to get into a clot

A

Findaparinux sodium (Arixtra)

39
Q

They keep the coagulation process in check and limited to local sites by degrading and activated coagulation factors that escape the injury site and remain within the formed clot

A

Natural inhibitors

40
Q

What is the flow of hemostatic process?

A

Vasoconstriction
Primary Platelet Plug
Secondary Platelet (Amplification - Propagation)
Fibrinolysis

41
Q

When does thrombin production ends?

A

With clot formation

42
Q

Factor ll

A

Thrombin

43
Q

What is the difference between hemostasis and coagulation?

A

Hemostasis is the overall stoppage of bleeding while coagulation is the process to achieve hemostasis

44
Q

Acute blood loss in the vein

A

Hemorrhage

45
Q

Responsible for production of platelets

A

Megakaryocyte

46
Q

What is the lifespan of platelet

A

About 10 days

47
Q

First line defense for inflammation

A

Monocyte

48
Q

It release histamine and heparin that enhances inflammatory response

A

Basophils

49
Q

What is RBC formation?

A

Erythropoiesis

50
Q

The process of erythropoiesis is regulated by

A

Erythropoietin

Phlebotomy Lecture Finals (8 decks)

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