Module 3 Flashcards
Factor I
Fibrinogen
Factor lll
Tissue Factor
Blood clot that forms in a large vein in the leg
Deep venous thrombosis
Pathological, widespread clotting and fibrinolysis at the same time, in which coagulation factors are consumed to such an extent that bleeding occurs
Disseminated intravascular coagulation (DIC)
Genetic disorder characterized by bleeding due to increased coagulation time
Hemophilia
Hemophilia A is also known as
Factor Vlll deficiency
Hemophilia B is also called as
Factor IX
Abnormal decrease in platelets
Thrombocytopenia
What are the tests for hemostatic process?
D-dimer
Factor Assays
Fibrin degradation products(FDP)
Platelet function assay (PFA)
Prothrombin time (PT)
Partial thromboplastin time(PTT / APTT)
What is the first coagulation disorder to be recognized during second century?
Hemophilia
A chronic, malignant disorder, common in males characterized by lymph node enlargement
Hodgkin disease
an infection of the lymphatic system caused by Epstein-Barr virus
Infectious mononucleosis
Infectious mononucleosis is caused by
Epstein-barr virus
Inflammation of the lymph vessels
Lymphangitis
Inflammation of one or more lymph nodes
Lymphadenitis
Disease of the lymph nodes, often associated with node enlargement such as seen in mononucleosis
Lymphadenopathy
Sometimes benign but usually malignant
Lymphoma
Term for lymphoid tumor
Lymphoma
Spleen enlargement
Splenomegaly
What are the tests for lymphatic system disorders?
Bone marrow biopsy
Complete blood count (CBC)
Lymph node buopsy
Mononucleosis (mono) test
Where is axillary lymph nodes located?
Nodes in the armpit
The process by which fibrin is dissolved
Fibrinolysis
What are the two activities of fibrinolysis?
Dissolves clots (thrombi) that form within intact vessels
Removes hemostatic clots from tissue as healing occurs
What substance converts plasmin?
Plasminogen
An enzyme that breaks down fibrin into smaller fragments called the degradation products
Plasmin
What do fibrin splits?
Products and D-dimer
Bleeding is associated with
Increased fibrinolytic activity
Thrombosis is associated with
Decrease fibrinolytic activity
What does the liver synthesize/s in hemostasis?
Factor V
Factor Vlll
Prothrombin
Fibrinogen
Who produce heparin naturally in the body?
Mast cells (tissue basophils) in the liver
What happens when liver is diseased?
Bleeding may result
Liver produces bile salts for
Absorption of Vitamin K
Vitamin K deficiency can result to
Elevated PT and APTT, and potential bleeding
Used for treating clotting disorders
Coumarins (coumadin and other warfarin trade names)
How does coumarin works?
By inhibiting the proper synthesis of the vitamin-K dependent factors
What are the three natural inhibitor?
Antithrombin (AT)
Heparin cofactor ll (HCll)
Proteins C and S
Developed to inactivate thrombin inside a clot and prevent clot propagation with clotting disorders, such as deep venous thrombosis
Drug fondaparinux sodium (Arixtra)
It is developed because antithrombin is too large to get into a clot
Findaparinux sodium (Arixtra)
They keep the coagulation process in check and limited to local sites by degrading and activated coagulation factors that escape the injury site and remain within the formed clot
Natural inhibitors
What is the flow of hemostatic process?
Vasoconstriction
Primary Platelet Plug
Secondary Platelet (Amplification - Propagation)
Fibrinolysis
When does thrombin production ends?
With clot formation
Factor ll
Thrombin
What is the difference between hemostasis and coagulation?
Hemostasis is the overall stoppage of bleeding while coagulation is the process to achieve hemostasis
Acute blood loss in the vein
Hemorrhage
Responsible for production of platelets
Megakaryocyte
What is the lifespan of platelet
About 10 days
First line defense for inflammation
Monocyte
It release histamine and heparin that enhances inflammatory response
Basophils
What is RBC formation?
Erythropoiesis
The process of erythropoiesis is regulated by
Erythropoietin
