Module 2.1 - Biofluid Transport I

Question 1

What causes flow to be turbulent?

Answer 1

Frictional forces in fluid causing eddies

Question 2

Simple respiratory flow model

Answer 2

• All conducting airways are represented as single, rigid tube
• All alveoli are grouped together as one single, compliant alveolus

Question 3

Alveolar pressure function

Answer 3

P_pl = < P_pl > + Del_P_pl * sin(omega*t)

< P_pl > = mean P_pl
Del_P_pl = amplitude
Omega = breath rate

Question 4

P_A, P_pl, V_A

Answer 4

P_A = alveolar pressure
P_pl = plural pressure (directionally radial)
V_A = volume of alveoli compartment

Question 5

Transpulmonary pressure

Answer 5

Difference betw intrapulmonary pressure and intrapleural pressure

Question 6

T/F: Intrapleural pressure is always negative

Answer 6

T

Question 7

What is the driving force of airflow in/out of lungs?

Answer 7

P_atm - P_A

(P_A = alveolar P)

Question 8

T/F: simple respiratory flow model represents airflow in/out of lungs worse than Windkessel model

Answer 8

F: better, but built on same foundation. Breathing is regular process (in/out, continuous) and we do not have issue of pulse

Question 9

Asthma

Answer 9

Inflammatory response triggered by exposure to an air-borne allergen (particulates, cold, etc.) that results in narrowing of airways

Question 10

T/F: Asthma will have airways clogged from swelling and mucus

Answer 10

T

Question 11

Normal breathing rate

Answer 11

12-15 breaths/min

Question 12

Driving force for lung expansion occurs through ______

Answer 12

Pleura