Module 2 : Neoplastic Disease Flashcards
typical US appearance of hemangioma of the liver
atypical US appearance of hemangioma
small, usually < 3cm
hyperechoic, homogenous and well defined
no colour flow
heterogenous w/ hypo central area
in which gender is FNH more common
why
women
influenced by hormones
describe FNH
hyperplastic leison made up of normal liver tissue in an abnormal configuration… next most common after hemangioma
can hemangiomas of the liver increase in size w/ preg or estrogen therapy (HRT)
yes
describe a hemangioma of the liver
most common benign tumor in the liver, made of many small blood capillaries
how will a hemangioma appear in a fatty liver
hypoechoic
US appearance of liver lipoma
hyperechoic
very similar to hemangioma
describe a liver adenoma
symptoms?
uncommon benign tumor, next most common after FNH
USUALLY asymp.
general info about benign neoplasms: symptoms lab tests appearance growth vascularity
often asymptomatic no change in lab tests well defined and encapsulated slow growing hypo or avascular
what 2 things are liver adenomas linked to
linked to BCPs and type 1 glycogen storage disease
2 risks associated w/ liver adenomas
hemorrhage or infarct due to large size
what is a neoplasm
can they be diffuse or focal
abnormal tissue growth, cells proliferating at a fast rate
yes
treatment for FNH
conservative, depends on size
what other types of imaging/testing can be used to correlate w/ the finding of a benign liver neoplasm
contrast CT, MRI RBC cell scintigraphy (nuch med) sulphur collloid contrast US biopsy
how will FNH look on a sulpher colloid nuch med scan
why
hot or warm
the kupffer cells will eat up the sulpher colloid
what does type 1 glycogen storage disease cause
another name for it
fatty liver and liver failure due to too much glycogen
Von Gierke’s Disease
follow up for hemangiomas of the liver
re-scan in 6 month and look for changes
describe an adenoma of the GB
the only true neoplasm of the GB, can be pedunculated
Are Desmoid tumors more common in M or W
What age grp
W due to C sections
20-40
best way to differentiate b/w FNH and adenoma
sulphur colloid… hard to differentiate on US
what does exophitic mean
‘sticking out’ of the organ
are most adenoma of the adrenal gland hyper or non functioning
non
describe adenomyomatosis
can it be focal or diffuse
exaggeration of the RA sinuses and proliferation of the smooth muscle wall of the GB which cause cholesterol crystals to become trapped in the walls
yes
if angiomyolipomas are exophitic, why can they be hard to see
blend in w/ renal fat
US appearance of an adenoma of the adrenal gland
solid, round
hypo
treatment for liver lipomas
conservative
Describe a pheochromocytoma of the adrenal gland
Symptoms
Hyperfunctiioning tumour of the medulla
Hypertension
Palpating
Tachycardia
Excessive sweating
are benign neoplasms of the spleen rare or common
rare
What lab tests will be evaluated w/ pheochromocytoma
Urinary catecholamines
what does ‘myelo’ mean
bone marrow or bone forming elements
pheochromocytomas are associated w/ which conditions
Tuberous sclerosis
MEN syndrome (multiple endocrine neoplasia… can be benign or malignant)
are myelolipomas of the adrenal gland more common in one gender
no
what does the term functioning refer to
hormone producing
describe angiomyolipomas (AML) in the kidney
arise from renal cortex
made up of blood vessels, muscle and fat
most common benign neoplastic mass of kidneys
Which tumors are the most common tumor of the abdo wall
Desmoid tumor
statistically, are most focal areas seen in the GB polpys or adenomas
polyps (65%)
How can pheochromocytomas effect the panc
Can displace panc tail anteriorly
is US conclusive in diagnosing a cavernous hemangioma in the spleen
why
no, due to variable appear.
describe a cavernous hemangioma/hemangioma or the spleen
congenital
most common benign neoplasm of the spleen, but not commonly seen
typically, are benign islet cell tumors usually functioning or non functioning
functioning… while most malignant ones are non functioning
angiomyolipomas are most common in which gender and age grp
women
middle age
US appearance of a myelolipoma of the adrenal gland
hyper, can blend in w/ perirenal fat
< 5 cm
propagation speed artifact
US appearance of angiomyolipomas in the kidney
hyper, well defined
unilateral usually
low blood flow
what benign liver neoplasm is rare in the liver but common in the body else-where
lipoma
how does adenomyomatosis effect the size of the GB wall
thickens it… will be >3 mm when distended
how will an adenoma appear on a sulphur colloid scan
cold
US appearance of Desmoid tumor
Hypo and homo
if larger, what malignancy can angiomyolipomas mimic
RCC
describe a hamartoma
US appearance
rare neoplasm composed of lymphoid tissue
homo, solid, echogenic
most common type of islet cell tumor….. is it benign or malignant
where is it typically located in the panc
insulinoma, benign
body or tail
describe tuberous sclerosis
fits and zits - seizures and skin growths
US appearance of FNH
‘stealth leison’
< 8 cm
central scar w/ doppler flow centrally
where in the GB is adenomyomatosis most common
fundus
another name for angiomyolipoma
renal hamartoma
called the hemangioma of the kidney
what is the easiest way to detect FNH when scanning
look for abnorm. contour/displaced vessels
is a hamartoma encapsulated
no
can polyps and adenomas of the GB be differentiated on US
no
when do myelolipomas of the adrenal gland present
5th - 6th decade
US appearance of GB adenoma
hyperechoic and homo
<10mm
avascular
US appearance of cavernous hemangioma of the spleen
variable
can adenomas/oncocytomas mimic RCC
yes, need biopsy to differentiate
symptoms/results of hyperfunctioning adenomas of the adrenal gland
endocrine abnormalities…
Cushings syndrome - increased cortisol
Conns disease - increased aldosterone
describe a myelolipoma of the adrenal gland
symptoms?
rare, non-functioning neoplasm that might arise from the zona fasciculate
can cause pain
what is cholesterolosis/strawberry GB
multiple non shadowing masses fixed to the GB wall
describe adenomas/oncocytomas in the kidney
symptoms?
- benign masses that present in the 6th-7t decade of life
- they are identical, differentiated only by size
possible hematuria, pain
describe islet cell tumors
most common tumor of the panc
can be benign or malignant, functioning or non functioning
angiomyolipomas are associated w/ which condition
how will angiomyolipomas present sonographically in these patients
tuberous sclerosis
bilateral and multiple angiomyolipomas
describe cholesterolosis in the GB
2 types
accumulation of cholestrol in the GB wall
- cholesterolosis (strawberry GB)
- cholesterol polyps
hemangiomas of the liver are more common in which gender
women - 5:1
US appearance of pheochromocytoma
Solid, unilateral
Hypo
Homo or hetero
>2cm
what are cholesterol polyps
focal form of cholesterolosis
describe a lipoma in the liver
symptoms?
very rare
USUALLY asymp.
describe an adenoma of the adrenal gland
arise from adrenal cortex
hyperfunctioning or non-functioning
single and unilateral usually
if adenomyomatosis effects the mid part of the GB how will it look
hour glass
size difference b/w adenomas and oncocytomas
Adeno: < 3 cm
onco: > 3 cm
US appearance of islet cell tumors
solid, solitary usually hypo (larger can be slightly echogenic) variable in size
US appearrance of a liver adenoma
variable- usually hyperechoic
8-15 cm
solid, single
central colour w/ doppler
Describe a lipoma of the abdo wall
US appearance
Made of fat, mobile and soft on palpation, compressible
Slightly hyper to highly echogenic
US appearance of adenomas/oncocytomas
well defined
hypo or iso
in which gender are adenomas/oncocytomas more common
males
which benign tumor is equally common in men and women
myelolipoma
Describe a Desmoid tumor in the abdo wall
Where is it located
Arises from c-tissue (aponeurosis or fascia) often found at a surgical or laparoscopic site
Anterior abdo wall usually
When do pheochromocytomas of the adrenal gland present
Are they more common on the R or L adrenal gland
4th - 5th decade of life
R
Us appearance of adenomyomatosis
hyperechoic foci in the GB wall w/ comet tail artifact
Are Desmoid tumors associated w/ post parting
Yes due to C section
what are adenomyomas in the GB
focal, mass like areas of adenomyomatosis
treatment for liver adenoma
surgery
Describe the growth of Desmoid tumors
Slow, infiltration locally
all masses are asymp. unless otherwise written
encapsulated unless otherwise written
/
describe a lymphangioma of the spleen
US appearance
rare neoplasm cause by lymphatic malformation
variable
can appear as a cystic lymphangiomyomatosis (multi-loculated cyst)
a GB adenoma < than what size is insignificant
<10mm
what are malignant neoplasms
2 different origins
cancerous growths
epithelial
connective tissue
what are 3 routes of spread for metastatic cancer
blood
lymphatics
direct invasion (cancer is in direct contact w/ another organ, facilitating spread)
HCC is specifically associated w/ which metabolic disorder
GSD - glycogen storage disease
another name for HCC
hepatoma
the disruption of the production of which protein produced by the liver may cause ascites?
albumin - controls osmotic balance
malignant neoplasms of which origin are most common
epithelial
risk factors for malignant neoplasms
viruses (HPV, Hep B and C)
family Hx
environment
hormones (HRT)
which lab values will be elevated w/ HCC
ALP AST ALT
and AFP
describe Hepatocellular carcinoma
what are its 3 forms
most common primary tumor of the liver occurring in the 6th decade of life
- focal solitary
- focal multiple
- diffuse infiltration
another name for hemangiosarcoma
angiosarcoma