Module 2 Ch. 10 lecture

Question 1

What is inflammation?

Answer 1

Protective function of the body. It is necessary, inflammation mediators cause pain and swelling

Question 2

What is needed to treat pain and swelling of simple inflammation that comes from disease?

Answer 2

NSAIDs (corticosteriods), ice, immobilization

Question 3

What is a corticosteriod?

Answer 3

A group of drugs that act like the bodies own cortisol.

Question 4

Where is cortisol produced in the boy?

Answer 4

In the outer part (cortex) of the adrenal gland.

Question 5

What is the function of the corticosteroids?

Answer 5

Modulate glucose levels (increase sugar levels) and body responses to stress.
Immune function that decreases the inflammatory response

Question 6

What is the mechanism of action?

Answer 6

Suppresses the COX enzymes,

also inhibit leuotrienes produced from the lipoxygenase enzyme.

Question 7

What are the down sides of corticosteroids?

Answer 7

When used for long periods of time body develops characteristics (body shape) and the person is said to be “cushioned” (fat people)
Muscle lose diabetes like
Fat in other areas develops

Question 8

How do we avoid or reduce systemic side affects?

Answer 8

We use it locally and and regionally instead of systemically

Question 9

Corticosteroids come in many varieties like creams, ointments, eye drops, ear drops, oral and systemic forms-for systemic use popular forms are…

Answer 9

oral prednisone
I.M. Kenalog (triamcinolone) “allergy shot”
I.V Solu-Medrol (methylprednisolone) used to treat emergency anifelective reactions