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Module 2 Flashcards

1
Q 
Loacation :- function 
GLUT 1 :- 
GLUT 2 :- 
GLUT 3 :- 
GLUT 4 :- 
GLUT 5 :- 
GLUT 8 :- 
GLUT 9 :-
A

Review 1

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2
Q 
Sites of various pathways in cells :- 
Mitochondrion 
1. 
2. 
3. 
4. 
5.
A

Review 6

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3
Q 
Cytoplasm 
1. ( imp ) 
2. ( imp ) 
3. 
4. 
5. 
6. 
7.
A

Revie 6

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4
Q

Both
1.
2.
3.

A

Review 6

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5
Q

Details of glycolysis :-

  1. Conversion of :-
  2. To:-
  3. For complete breakdown :-
  4. Net ATP from aerobic :- & anaerobic :-
  5. No of ATP used :-

RBC lacks :-

Rate limiting enzyme of glycolysis :- 
Irreversible steps in glycolysis are by :- 
1. 
2. 
3.

Steps releasing ATP. In glycolysis :-

Inhibitors of glycolysis
1.
2.
3.

A

Review 7

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6
Q

Revise glycolysis cycle

A

Review 7

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7
Q 
Irreversible steps in glycolysis are :- 
1. 
2. 
3. 
Image of cycle
A

Review 8 from image of cycle

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8
Q

Rate determining enzymes and key regulator:-

  1. Glycolysis :- ,,,,,,,,,,,,,,,,:- ,,,,,,,,,,,,,
  2. Gluconeogenesis :- ,,,,,,,,,,,,,,,,,:- ,,,,,,,,,
  3. Kerb cycle / TCA cycle :-,,,,,,,,,,,,:- ,,,,,,,,,,
    4.Glycogenesis :-…………….
  4. Glycogenolysis :- ,,,,,,,,,,,,,,,,,,
  5. HMP shunt:- ,,,,,,,,,,,,,,,,,
  6. Pyrimidine synthesis:-,,,,,,,,,,,,,,,,,
  7. Purine synthesis:- ,,,,,,,,,,,,,,,,,
  8. Urea cycle :- ,,,,,,,,,,,,,,,,,
  9. Fatty acid synthesis:- ,,,,,,,,,,,,,,,
  10. Fatty acid oxidation :- ,,,,,,,,,,,,,,,
  11. Cholesterol synthesis :-,,,,,,,,,,,,,
    13.
A

Review 9

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9
Q

Key regulator
1. Glycolysis :- ,,,,,,,,,,,,,,,,:- ,,,,,,,,,,,,,
2. Gluconeogenesis :- ,,,,,,,,,,,,,,,,,:- ,,,,,,,,,
3. Kerb cycle / TCA cycle :-,,,,,,,,,,,,:- ,,,,,,,,,,
4.Glycogenesis :-…………….
5. Glycogenolysis :- ,,,,,,,,,,,,,,,,,,
6. HMP shunt:- ,,,,,,,,,,,,,,,,,
7. Pyrimidine synthesis:-,,,,,,,,,,,,,,,,,
8. Purine synthesis:- ,,,,,,,,,,,,,,,,,
9. Urea cycle :- ,,,,,,,,,,,,,,,,,
10. Fatty acid synthesis:- ,,,,,,,,,,,,,,,
11. Fatty acid oxidation :- ,,,,,,,,,,,,,,,
12. Cholesterol synthesis :-,,,,,,,,,,,,,
13.

A

Review 9

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10
Q

Hexokinase vs glucokinase :-

  1. Tissue distribution:-
  2. Km:-
  3. Vmax :-
  4. Inhibition by G6PD :-
  5. Inducible :-
  6. Clinical significance :-
  7. Biological significance:-

Graph :-

A

Review 11:-

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11
Q

1st commuted step in glycolysis:-

A

Review 12

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12
Q 
Anaerobic glycolysis:- 
Catalyse by :- 
End product :- 
ATP :- 
In RBC :- 
NADH :-
A

Review 13

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13
Q

Pyruvate metabolism :- and conversion

  1. :-
  3. ( easy )
  4. ( easy )
A

Review 13

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14
Q

Step in glycolysis using inorganic phosphate:-

Enzyme :-

A

Review 14 :

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15
Q

Reaction taking part in substrate level phosphorylation:-
1.
2.

A

Review 15

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16
Q 
How ATP formed in glycolysis
Reaction enzyme product ATP 
1. :- 
2. = 
3. =

How 9 ATP are produced :-

17
Q

Idoacetate inhibits :-
Fluoride inhibits :-
Arcinate inhibits :-

18
Q

Fluoride in blood sample :-

Potassium oxalate :-

19
Q

Inhibitors of metabolic pathway

Glycolysis

Inhibitors of TCA cycle :-

Inhibitors of electron transport 
Complex 1 :- 
Complex 2 :- 
Complex 3 :- 
Complex 4 :-

Inhibitors of oxidative phosphorylation
1.
2.

20
Q

Fructose 2,6 bisphosphate is the :-

21
Q

Cause of haemolytic anemia

  1. MC deficiency of:-
  2. Second MC :-
22
Q

Rapaport Leubering cycle occurs in :-

23
Q

Cancer cells derives energy by with pathway :-

Warburg effect :-

24
Q 
Gluconeogenisis occurs in which organs 
1. 
2. 
Gluconeogenesis is process of conversion of :- 
Occurs in :- 
Of :-

Lactate generates in many tissues are transported to :-
Converted to :-
By cycle :-
Glucose alanine cycle is referred as :-

Muscle cannot participate in gluconeogenesis as it lack :-

25
Q

Irreversible enzymes in gluconeogenesis pathway are

Mnemonic is :
Pathway Produce Fresh Glucose 
P= 
P=
F=
G=
26
Q

Transport of ammonia in blood ( Cahill and cori cycle )

27
Q 
Substrate for gluconeogenesis 
LPGP
1. 
2. 
3. 
4.
28
Q

Coris cycle :-

29
Q

Organ involved in Cahill cycle
Alanine from :-
To :-

30
Q

Malate shuttle is important in :-
1.
2.

31
Q

Pyruate carboxylase

Inducer is :-
Repressor is :-
Activator is :-
Inhibitor is :-

32
Q

Gluconeogenesis

Read the pathway :-

A

Review 28,29

33
Q

Fasting state increase or decrease

  1. Gluconeogenesis :-
  2. Gycogenolysis :-
  3. Ketogenesis :-
  4. Glycogen storage :-
34
Q

Read 31

35
Q

Phosphorylated state means insulin is:-

Dephosphorylated state :-

36
Q

In high insulin ( dephosphorylated state )

Cholesterol synthesis :- 
FA synthesis :- 
Glycogen synthesis : 
Glycolysis :- 
Pyruvate dehydrogenase:-
37
Q

Active in low insulin ( phosphorylated state )
Remaining pathway :-

i.e Pathway Produce Fresh Glucose
Glycogenolysis :-
Lipase which is active is :-

Pharmacology + Biochemistry (3 decks)

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