Module 2

Question 1

Loacation :- function 
GLUT 1 :- 
GLUT 2 :- 
GLUT 3 :- 
GLUT 4 :- 
GLUT 5 :- 
GLUT 8 :- 
GLUT 9 :-

Answer 1

Review 1

Question 2

Sites of various pathways in cells :- 
Mitochondrion 
1. 
2. 
3. 
4. 
5.

Answer 2

Review 6

Question 3

Cytoplasm 
1. ( imp ) 
2. ( imp ) 
3. 
4. 
5. 
6. 
7.

Answer 3

Revie 6

Question 4

Both
1.
2.
3.

Answer 4

Review 6

Question 5

Details of glycolysis :-

1. Conversion of :-
2. To:-
3. For complete breakdown :-
4. Net ATP from aerobic :- & anaerobic :-
5. No of ATP used :-

RBC lacks :-

Rate limiting enzyme of glycolysis :- 
Irreversible steps in glycolysis are by :- 
1. 
2. 
3. 

Steps releasing ATP. In glycolysis :-

Inhibitors of glycolysis
1.
2.
3.

Answer 5

Review 7

Question 6

Revise glycolysis cycle

Answer 6

Review 7

Question 7

Irreversible steps in glycolysis are :- 
1. 
2. 
3. 
Image of cycle

Answer 7

Review 8 from image of cycle

Question 8

Rate determining enzymes and key regulator:-

1. Glycolysis :- ,,,,,,,,,,,,,,,,:- ,,,,,,,,,,,,,
2. Gluconeogenesis :- ,,,,,,,,,,,,,,,,,:- ,,,,,,,,,
3. Kerb cycle / TCA cycle :-,,,,,,,,,,,,:- ,,,,,,,,,,
   4.Glycogenesis :-…………….
4. Glycogenolysis :- ,,,,,,,,,,,,,,,,,,
5. HMP shunt:- ,,,,,,,,,,,,,,,,,
6. Pyrimidine synthesis:-,,,,,,,,,,,,,,,,,
7. Purine synthesis:- ,,,,,,,,,,,,,,,,,
8. Urea cycle :- ,,,,,,,,,,,,,,,,,
9. Fatty acid synthesis:- ,,,,,,,,,,,,,,,
10. Fatty acid oxidation :- ,,,,,,,,,,,,,,,
11. Cholesterol synthesis :-,,,,,,,,,,,,,
    13.

Answer 8

Review 9

Question 9

Key regulator
1. Glycolysis :- ,,,,,,,,,,,,,,,,:- ,,,,,,,,,,,,,
2. Gluconeogenesis :- ,,,,,,,,,,,,,,,,,:- ,,,,,,,,,
3. Kerb cycle / TCA cycle :-,,,,,,,,,,,,:- ,,,,,,,,,,
4.Glycogenesis :-…………….
5. Glycogenolysis :- ,,,,,,,,,,,,,,,,,,
6. HMP shunt:- ,,,,,,,,,,,,,,,,,
7. Pyrimidine synthesis:-,,,,,,,,,,,,,,,,,
8. Purine synthesis:- ,,,,,,,,,,,,,,,,,
9. Urea cycle :- ,,,,,,,,,,,,,,,,,
10. Fatty acid synthesis:- ,,,,,,,,,,,,,,,
11. Fatty acid oxidation :- ,,,,,,,,,,,,,,,
12. Cholesterol synthesis :-,,,,,,,,,,,,,
13.

Answer 9

Review 9

Question 10

Hexokinase vs glucokinase :-

1. Tissue distribution:-
2. Km:-
3. Vmax :-
4. Inhibition by G6PD :-
5. Inducible :-
6. Clinical significance :-
7. Biological significance:-

Graph :-

Answer 10

Review 11:-

Question 11

1st commuted step in glycolysis:-

Answer 11

Review 12

Question 12

Anaerobic glycolysis:- 
Catalyse by :- 
End product :- 
ATP :- 
In RBC :- 
NADH :-

Answer 12

Review 13

Question 13

Pyruvate metabolism :- and conversion

1. :-
3. ( easy )
4. ( easy )

Answer 13

Review 13

Question 14

Step in glycolysis using inorganic phosphate:-

Enzyme :-

Answer 14

Review 14 :

Question 15

Reaction taking part in substrate level phosphorylation:-
1.
2.

Answer 15

Review 15

Question 16

How ATP formed in glycolysis
Reaction enzyme product ATP 
1. :- 
2. = 
3. = 

How 9 ATP are produced :-

Answer 16

Review 16

Question 17

Idoacetate inhibits :-
Fluoride inhibits :-
Arcinate inhibits :-

Answer 17

Review 17

Question 18

Fluoride in blood sample :-

Potassium oxalate :-

Answer 18

Review 17

Question 19

Inhibitors of metabolic pathway

Glycolysis

Inhibitors of TCA cycle :-

Inhibitors of electron transport 
Complex 1 :- 
Complex 2 :- 
Complex 3 :- 
Complex 4 :- 

Inhibitors of oxidative phosphorylation
1.
2.

Answer 19

Review 17

Question 20

Fructose 2,6 bisphosphate is the :-

Answer 20

Review 18

Question 21

Cause of haemolytic anemia

1. MC deficiency of:-
2. Second MC :-

Answer 21

Review 19

Question 22

Rapaport Leubering cycle occurs in :-

Answer 22

Review 20

Question 23

Cancer cells derives energy by with pathway :-

Warburg effect :-

Answer 23

Review 22

Question 24

Gluconeogenisis occurs in which organs 
1. 
2. 
Gluconeogenesis is process of conversion of :- 
Occurs in :- 
Of :- 

Lactate generates in many tissues are transported to :-
Converted to :-
By cycle :-
Glucose alanine cycle is referred as :-

Muscle cannot participate in gluconeogenesis as it lack :-

Answer 24

Review 22

Question 25

Irreversible enzymes in gluconeogenesis pathway are

Mnemonic is :
Pathway Produce Fresh Glucose 
P= 
P=
F=
G=

Answer 25

Review 22

Question 26

Transport of ammonia in blood ( Cahill and cori cycle )

Answer 26

Review 22

Question 27

Substrate for gluconeogenesis 
LPGP
1. 
2. 
3. 
4.

Answer 27

Review 23

Question 28

Coris cycle :-

Answer 28

Review 24

Question 29

Organ involved in Cahill cycle
Alanine from :-
To :-

Answer 29

Review 25

Question 30

Malate shuttle is important in :-
1.
2.

Answer 30

Review 26

Question 31

Pyruate carboxylase

Inducer is :-
Repressor is :-
Activator is :-
Inhibitor is :-

Answer 31

Review 27

Question 32

Gluconeogenesis

Read the pathway :-

Answer 32

Review 28,29

Question 33

Fasting state increase or decrease

1. Gluconeogenesis :-
2. Gycogenolysis :-
3. Ketogenesis :-
4. Glycogen storage :-

Answer 33

Review 30

Question 34

Read 31

Answer 34

Review 31

Question 35

Phosphorylated state means insulin is:-

Dephosphorylated state :-

Answer 35

32

Question 36

In high insulin ( dephosphorylated state )

Cholesterol synthesis :- 
FA synthesis :- 
Glycogen synthesis : 
Glycolysis :- 
Pyruvate dehydrogenase:-

Answer 36

Review 3

Question 37

Active in low insulin ( phosphorylated state )
Remaining pathway :-

i.e Pathway Produce Fresh Glucose
Glycogenolysis :-
Lipase which is active is :-

Answer 37

Review 32