Module 12 Flashcards
Pharmacological Approaches to Obesity
1
Q
What are the 3 benefits of incretins?
A
- Are associated with better glucose management
- Are associated with improved cardiovascular outcomes
- Have appetite-reducing, weight-reducing effect
2
Q
What are the effects of semaglutide and liraglutide?
They’re the same
A
- Increases insulin, reduces blood glucose
- Slows gastric emptying
- Decreases appetite
3
Q
Why are tirzepatides associated with larger amounts of weight loss than semaglutides and liraglutides?
A
Dual agonism of GLP-1 and GIP
4
Q
How does orlistat work to promote weight loss?
A
It blocks lipase, thus dietary fat (30%) can’t be broken down and absorbed.
5
Q
List 4 negative side effects of orlistat.
A
- Can negatively impact absorption of fat-soluble vitamins
- Oily stools
- Flatulence
- Fecal incontinence
6
Q
What is Naltrexone?
How does Buproprion work?
How does the combination of these help treat obesity?
A
- Naltrexone is a competitive antagonist for the μ-opioid receptor
- Buproprion is an NDRI that activates POMC neurons in the
hypothalamus - Modulate reward circuitry associated with food wanting
7
Q
Who are the Buproprion / Naltrexone drugs best suited for?
A
- People with dependency issues
- People with history of GI issues
Note: Not as effective at weight loss as GLP-1 agonists
