Module 10 - Start of Final Exam Flashcards
Renal
Kidney
Retroperitoneal
location of the kidneys behind the peritoneal area
Because the kidneys are outside the peritoneal sac, peritoneal cancer does not spread as easily to them
Ureters can do ___ movement
Peristalsis
Urine leaves in ___
drips (not a flow)
Detrusor Muscle
Muscle of the bladder that can stretch for holding more urine or constrict/hang on to urine during a fight or flight response until a stressor is resolved
CV Angle
costovertebral angle
90 degree angle below the 12th rib that is over each kidney
tenderness ion this area can infer that there is a kidney infection ocurring
Where are the kidneys located?
Attached to the ab wall at the level of the last thoracic and first three lumbar vertebrae
it is enclosed in a renal capsule in this retroperitoneal area
Renal Cortex
Outer layer of the renal capsule
It has cortical nephrons
Renal Medulla
Middle part of the kidney surrounded by the renal cortex
Has medullary nephrons
Parenchymal Tissue of the Kidneys
Nephrons
Cortical Nephrons
Shorter nephrons not penetrating the kidneys as deeply
part of the renal cortex
less concentrating power on filtrate than the medullary nephrons
Medullary Nephrons
Nephrons going deeper into the kidney with stronger concentrating power on filtrate than the cortical nephrons
Consequently, if these nephrons are damaged there will be more H ion, water, electrolyte loss than if the cortical ones were damaged
Functions of the Kidneys
Maintain blood homeostasis
Excrete body metabolism end products
Control fluid and electrolyte balance
Excrete bacterial toxins, water soluble drugs, and drug metabolites
Secrete Renin and erythropoietin
Play a role in the function of the parathyroid hormones and vitamin D
Low flow states to the kidney causes …
renin secretion
Angiotensin II is a potent…
vasoconstrictor (increasing preload and afterload as a result)
What part of the kidney does aldosterone work on?
the distal convoluted tubule to control sodium (which water then follows)
Nephron
Parenchymal functional renal unit
Made up of glomerulus and tubules
The filtering system of the kidneys
Nephrons
What determines the amount of filtering done in the nephrons?
The amount of pressure coming into the system (increase = increase)
Proximal Convoluted Tubule
part of the nephron
Afferent and Efferent flow - arterial/pressure associated in nature
Mechanisms of flow here help the glomerulus do filtering while reclaiming things like water and glucose
Should there be glucose in urine?
No, not normally
Diabetic ketoacidosis and other issues can lead to this being in the urine
Loop of Henle
Concentrating mechanism of the nephron
Has differential permeability to urea in water
One of the more fragile parts of the nephron
Nocturia
Nocturnal voiding without reason for it
Isosthenuria
isotonic urine where urine has the same tenacity as blood
If there is an insult to the nephron, which area is most likely to go and lead to loss of concentrating ability?
the loop of henle
Concentrating Mechanism of the Nephron
Loop of Henle
Distal Convoluted Tubule
Area of the nephron where aldosterone acts to retain sodium and water (passively)
This is an area where more fine tuning is done in exchanging of things
Acid Base of Electrolyte Balance has its fine tuning done here
Vasa Recta
blood supply along the loop of Henle
Venous flow from the nephrons go to …
the Renal Vein
Collecting Duct
part of the nephron where ADH works - posterior pituitary with high blood osmolarity causes ADH release, which waters down the blood. The collecting duct will be worked on to prevent water from leaving the body and the ADH controls the water not the sodium
What glands sit on top of the kidneys
The Adrenal Glands
Glomerulus
In the nephron
Filtering part of the nephron
Encased in a bowmans capsule
Filters fluid, glucose, and tiny things - not large things like plasma proteins and RBC
If there is RBC or Plasma Proteins in the urine what might this give a picture of?
Inflammation because the glomerulus cells must be inflamed/enlarged and spread out enough to allow outflow
Post Streptococcal Glomerulonephritis
Inflammation in the glomerulus because of a strep infection, which leads to RBC and plasma proteins in the urine that should not be there
Tubules
Proximal, Distal, and Henle’s Loops areas of the kidney
Fluid is converted into urine at the tubules –> Urine moves to the Kidney Pelvis –> Urine flows from kidney pelvis to ureter –> Bladder –> Void
Filtrate
fluid , before conversion to urine by the tubules
Order of tubule filtration movement?
Renal Corpuscle –> Proximal Tubule – Loop of Henle –> Distal Tubule –> Collecting Duct
Urine Production
Fluid flows through the proximal tubules which leads to water and solute reabsorption
Whatever is not reabsorbed becomes urine and the process of selective reabsorption determines the amount of water and solutes to be secreted each time
Prostate Gland
Not a renal part, but has an effect on it in males
Surrounds the male urethra
Has a duct that opens into the prostatic portion of the urethra and secretes the alkaline part of seminal fluid
Enlarges with age and can put pressure on the urethra which can cause issues with voiding and thus increased UTI chance
Secretion
moving something from one place to another but it stays in the body
Excretion
moving something from one place to another but it leaves the body
The kidneys __ what we need and ___ what we dont
keep what we need and void what we dont
Risk Factors for Renal Disorder
Frequent UTI
High Na Diet
Contact Sports
Trauma and Injury
History of HTN
Family History of Renal Disease
Medication Use
Associated Medical Conditions like Diabetes
Why can frequent UTIs cause renal disorders
they can cause scarring
How can high Na diets lead to renal disorders
the kidneys have to do more fine tuning to get rid of all the salt we do not need
Renal disorders can occur when there is injury/trauma to the ….
flank area
How can HTN lead to renal disorderss
HTN, CAD, stroke, etc - HTN effects the whole body and since the flow state is important in this system, HTN can be a deterrent to glomerular filtration
How can medicines cause renal disorders
Things like chemotherapy drugs can be nephrotoxic
BUN Renal Function Test
Blood urea Nitrogen (mg/dL)
Measures how much nitrogen is coming from urea, and urea is a waste product of the liver when proteins are broken down
Decreased solvent in blood will increase BUN (decreases in water) SO THIS IS USED TO MEASURE DEHYDRATION
- not a good measure of kidney function on its own
Serum Creatinine Renal Function Tests
Serum Creatinine is waste products of the muscle (mg/dL)
a MUCH better indicator of renal function than BUN
Measures the creatinine content in serum (blood) and urine, and creatinine should not be reabsorbed so it SHOULD BE IN THE URINE
If there is high blood value, then filtering is not working
Creatinine Clearance Renal Function Tests
This is the amount of blood cleaned of creatinine by the kidneys (mL/min)
This value will greatly increase as kidney glomerulus filtration ability decreasesw
Uric Acid Serum and Uric Acid Urine Renal Function Tests
Waste product of purine breakdown seen in blood and urine (mg/dL for serum and mg/24 hours for urine)
Most uric acid is dissolved and secreted by the kidney, but it can buildup and cause gout, so it should be in urine
Both creatinine and uric acid test are done …
over 24 hours to check the urine
Uric acid buildup can lead to ….
gout
Purines are found in what foods?
Beer
Liver
Beans
Anchovies
Peas
(So eating more of these can lead to higher uric acid levels)
Urinalysis
the main way to test for renal system function and look for renal disease progression/existence
ex: Used when suspected UTI
What could cause false positive blood in the urinalyses?
menstruation
Implementation of Urinalsysi
Wash the perineal area
Use a clean container
Obtain 10-15 mL of first morning sample
- Refrigerated samples may alter specific gravity
- If menstruating, indicate so on lab form
2 Main Components of urinalysis
Physical Examination
Chemical Examination
Physical Examination of Urinalysis involves…
Color
Clarity
Specific Gravity
*water has a sg of 1, dilute urine is 1.002 and higher levels mean more dehydration (range is 1 to 1.030)
Chemical Examination of Urinalysis involves…
Urine pH Proteins Glucose Ketones Blood Bilirubin Urobilinogen WBCs Nitrites Leukocyte Esterase
pH of urine should be…
slightly acidic (4 to 6) since more alkaline urine increases rate of infection
If there is proteins, RBC, or glucose in urine what might it indicate?
Inflammation or High Blood Sugar
Ketone Presence in urine
Byproduct of fat metabolism that builds up in urine
Usually abnormal unless they are doing the Atkins Diet which WANTS ketotic urine
High ketones could indicate diabetic ketoacidosis
Bilirubin Presence in urine
Byproduct of RBC breakdown after 120 days and needs to be conjugated by the liver to be in the urine
Urobilinogen
Byproduct of conjugation of the bilirubin
Half of all of it should be excreted by the kidneys
What does WBC in urine indicate?
infection
Nitrite Presence in Urine
Indicates bacterial infection since the bacteria may have an enzyme that converts nitrates to nitrites
Leukocyte Esterase presence in urine
Enzyme secreted by WBC
Is a value that can help detect WBC in urine
Specific Gravity
A urine test that measures the specific gravity of the urine - which is the weight of urine in comparison to distilled water (1)
It evaluates concentrating and excretory abilities of the kidneys and hydration status
Essentially, measures amount of solutes in the fluid and a thicker fluid has a higher osmolarity and gravity