Module 1: Development of the Human Reproductive System Flashcards
Basic components of the reproductive system
-gametes
-gonads
-reproductive ducts
-external sex organs
Haploid cells
-after gametogenesis resulting haploid will only contain one sex chromosome
The SRY gene
-presence of this gene will determine the process of gonadal differentiation
-found on the y chromosome
SRY in males
-present
-activates genes present required for development of testes at week 7
SRY in females
-not present
-different genes are expressed that lead to development of oogonia and ovaries
Intersex disorders
-cause physiological variations in sexual characteristics that do not fit the typical definition of female or male
Turner syndrome
-condition in which female is partially or completely missing one of her X chromosomes
-causes non-functioning ovaries, heart defects, hormonal imbalances and impaired skeletal development
Sex linked disorders
-caused by genetic abnormalities inherited through sec chromosomes only
-do not necessarily affect sexual characteristics of individual
Example of sex linked disorders
-color blindness
Early blastocyst
-inner layer is embryoblast
-outer layer is trophoblast
Late blastocyst
-embryoblast differentiates into epiblast and hypoblast
Gastrulation
-the embryo differentiates into 3 germ layers
3 germ layers of trilaminar disc
-ectoderm
-mesoderm
endoderm
What layer forms the reproductive system
-mesoderm
What weeks does embryonic folding take place
-weeks 3 and 4
Gonadal ridge appearance weeks
-4
Primordial germ cells
-earliest cells associated with emergence of gonads
Primary sex cords
-finger like tissue projections formed from gonadal rudges
When do primary sex cords begin to form primitive testes
-weeks 7-8
Testosterone
-directs the development of male reproductive ducts
DHT
-synthesized from testosterone and will direct the development of external male genitalia
When does descent of the testes begin
-month 3
When does gubernaculum develop
-week 7
Gubernaculum function
-between week 7-12 it shortens to pull testes towards future location in labioscrotal swelling
Female gonad development
-in absence of SRY the primary sex cords degenerate and cortical sex cords begin to develop
-cortical cords eventually form ovarian follicles
What does gubernaculum go on to form in women
-round ligament of uterus
Migration abnormalities
-inguinal hernias
-undescended testes
-cryptorchidism
Why are males more prone to inguinal hernias than females
-when testes descend they create a gap in abdominal muscle after birth
Cryptorchidism
-occurs when one or both testes fail to complete their migration toward the scrotum
How do the male and female ducts develop
-wolffian ducts
-mullerian ducts
Where do wolffian and mullerian ducts originate
-intermediate mesoderm
Mullerian duct regression in males
-testosterone and AMH cause them to regress by week 8
What do wolffian ducts form in males
-ejaculatory ducts
-seminal vesicles
-vas deferens
-epididymis
Wolffian duct regression in females
-regress by week 10 of development
What do mullerian ducts form in females
-fallopian tubes
-uterus
-upper portion of vagina
External genitalia development males
-cloacal folds form by week 5
-cloacal folds differentiate into urogenital and anal folds by week 7
-exposure to DHT results in growth of genital tubercle and genital swellings by week 10
-genital tubercle continues to grow to form phallus, and urogenital folds fuse to form scrotum
External genitalia development females
-cloacal folds form by week 5
-cloacal folds differentiate into urogenital and anal folds by week 7
-minimal growth of genital tubercle and swellings by week 10
-genital tubercle develops into clitoris, urogenital folds do not fuse and give rise to labia majora and minora
Disorders of sex development
-xx male syndrome
-5-alpha-reductase deficiency
-androgen insensitivity syndrome
XX male syndrome
-genetic females with 2 x chromosomes that develop male reproductive structures
5-alpha-reductase deficiency
-genetic males with abnormal development of external sex organs
Androgen insensitivity syndrome
-genetic males with x-linked recessive mutation leading to insensitivity to androgens
Penile tissues
-2 corpora cavernosa
-1 corpus spongiosum