Module 0: Overview of Obesity

Question 1

Economics of obesity (2 points)

Answer 1

-Medical costs
-Lost productivity

Question 2

Obesity and life expectancy relationships

Answer 2

-Younger age of obesity development = greater impact on quality of life and life expectancy
-More obese = more years lost

Question 3

Management of obesity in healthcare (3 points)

Answer 3

1.Lifestyle (diet, exercise)
2.Medical (orlistat, lorcaserin)
Surgical (bariatric surgery)

Question 4

What do orlistat and lorcaserin do?

Answer 4

Orlistat: block lipid absorbtion in gut by inhibiting lipase enzyme
Lorcaserin: Appetite suppressant by activating POMC neurons in hypothalamus

Question 5

Weight loss & weight gain relationships with cell number and size

Answer 5

Weight loss: decrease cell size/ maintain cell number
Weight gain: increase cell size and number

Question 6

3 types of obesity

Answer 6

Caused mainly by genes (rare cases):
Monogenic and syndromic high efficacy treatment)

Caused by mainly environment, partly genes (common obesity):
Polygenic (mixed efficacy treatment)

Question 7

What is the FTO gene/what allele is associated with increased food intake and reduced satiety response?

Answer 7

-Fat mass and obesity-related gene
-A allele
*May be more responsive to high-protein diets