MODIFICATION OF MENDELIAN RATIOS Flashcards
ALLELES ALTER PHENOTYPES IN DIFFERENT WAYS:
most frequently encountered allele in a population, arbitrarily considered as normal.
WILD-TYPE ALLELE
ALLELES ALTER PHENOTYPES IN DIFFERENT WAYS:
Modification of genetic sequence
MUTATION
ALLELES ALTER PHENOTYPES IN DIFFERENT WAYS:
Mutation that brough about diminished functionality of the gene
LOSS OF FUNCTION MUTATION
ALLELES ALTER PHENOTYPES IN DIFFERENT WAYS:
Eventual loss of function of a gene due to mutation
NULL ALLELE
ALLELES ALTER PHENOTYPES IN DIFFERENT WAYS:
Increased activity of a gene due to mutation
GAIN OF FUNCTION MUTATION
ALLELES ALTER PHENOTYPES IN DIFFERENT WAYS:
Mutation in a gene that does not necessarily altered its activity
NEUTRAL MUTATION
GENETICISTS USE A VARIETY OF SYMBOL FOR ALLELES:
Lowercase and italicized (dd)
RECESSIVE ALLELE
GENETICISTS USE A VARIETY OF SYMBOL FOR ALLELES:
Uppercase and italicized (DD)
DOMINANT ALLELE
In a population of organisms, the presence of three or more alleles of the same gene.
MULTIPLE ALLELES
The ABO Blood Group was discovered by
KARL LANDSTEINER
The simplest case of multiple alleles is that which three alternative alleles of one gene exist
THE ABO BLOOD GROUP
A rare variant of the ABO antigen system in which affected individuals do not have A or B antigens and thus appear to have blood type O, even though their genotype may carry unexpressed alleles for the A and/or B antigens.
THE BOMBAY PHENOTYPE
Genetic mutation which might lead to death
Genes function primarily for the expression/production of substances essential to life,
LETHAL ALLELES
LETHAL ALLELES:
The lethal mutation is present (mutation that leads to total non-functionality of the gene) but there is another allele that may compensate.
HETEROZYGOUS RECESSIVE LETHAL ALLELE
LETHAL ALLELE:
Lethal indeed
HOMOZYGOUS RECESSIVE LETHAL ALLELE