Modelling

Question 1

What does Pharmacokinetics describe

Answer 1

Description of the temporal behavior of a drug concentration in the organism

Question 2

Dynamic Processes in Body

Answer 2

Absorption
Distribution
Elimination

Question 3

Zero & First Order Kinetics

Answer 3

Zero-order:
- Rate of concentration C is constant –> dC/dt = k

First-order:
- Rate of concentration change is directly proportional to the substances concentration –> dC/dt = - k*C

Question 4

Two-Compartment Model with Single Dose

Answer 4

Single dose with 1st order absorption

–> Bateman function! = impulse response of a 2nd order system

Question 5

Concentration-Effect Characteristic curve

Answer 5

2 Kennwerte:

1) Minimal effective concentration (MEC) –> bei 30%
2) Minimal toxic concentration (MTC) –> bei 75%

–> used for optimal adjustment of drug treatment

Question 6

Name 4 energy forms

Answer 6

• Mechanical
• Thermal
• Electric
• Chemical

Question 7

What is the Clearance in Pharmacokinetics?

Which unit?

Answer 7

Excreted amount of substance per unit of time
/
concentration in the distribution space

• unit: volume/time

Question 8

Which distribution spaces exist in the body?

Answer 8

intracellular

extracellular

body water

cell membrane