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Nerveux 3 - 1 > Mode d'action antiépileptique > Flashcards

Mode d'action antiépileptique Flashcards

1
Q

Phénytoine

A

Na

Effet : diminution transmission excitation et diminution décharges répétitives

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2
Q

Carbamazépine

A

Na

Effet : diminution transmission excitation et diminution décharges répétitives

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3
Q

Zarontin

A

Ca (type T)

Effet : augmentation seuil excitabilité

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4
Q

Phenobarbital

A

Ca (L et N)
Augmentation transmission inhibitrice (+++) (activation et modulation GABAa)
Diminution transmission excitatrice (antiglutamatergique par AMPA)

Effet : augmentation seuil excitabilité et potentialise effet GABA en agissant sur le site barbiturique

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5
Q

BZD

A

Augmentation transmission inhibitrice (+++) (modulation GABAa)

Effet : potentialise GABA en agissant sur site allostérique

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6
Q

Valproate

A

Na
Ca
Augmentation transmission inhibitrice (++) (action voie GABA)
Diminution transmission excitatrice

Effet : diminution transmission excitation, diminution décharges répétitives, potentialise GABA, inhibition GSK-3b?

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7
Q

Lamotrigine

A

Na>Ca (N et P)
Diminution transmission excitatrice (bloc AMPA) (réduction libération glutamate?)

Effet : diminution transmission excitation et diminution décharges répétitives

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8
Q

Oxcarbamazépine

A

Na>Ca=K

Effet : diminution transmission excitation et diminution décharges répétitives

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9
Q

Zonisamide

A

Na

Ca

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10
Q

Vigabatrine

A

Augmentation transmission inhibitrice (+++) (inhibition dégradation GABA, par inhibition GABA-T irréversible)

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11
Q

Tiagabine

A

Augmentation transmission inhibitrice (+++) (inhibe recapture GABA sur protéine transport)

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12
Q

Gabapentin

A

Na
Ca (a2d)
Augmentation transmission inhibitrice (+)

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13
Q

Felbamate

A

Na
Ca
Augmentation transmission inhibitrice (++)
Diminution transmission excitatrice (++)

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14
Q

Topiramate

A

Na
Ca
Augmentation transmission inhibitrice (++) (action GABA mimétique)
Diminution transmission excitatrice (++) (bloc AMPA et kainite)

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15
Q

Keppra

A

Ca
Na
Augmentation transmission inhibitrice (++)
Diminution transmission excitatrice

Bref : liaison SV2a (protéines vésicules synaptiques)

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16
Q

Pregabalin

A

Ca (a2d) > Na

Augmentation transmission inhibitrice (+)

17
Q

Lacosamide

A

Na

Interaction aussi avec DPYSL2

18
Q

Rufinamide

19
Q

Perampanel

A

Diminution transmission excitatrice (+++) (bloc AMPA)

20
Q

Eslicarbamazépine

A

Na>ca=k

Effet : diminution transmission excitation et diminution décharges répétitives

Idem Oxcarbamazépine

21
Q

Ezogabine

A

K

Effet : hyperpolarisation membrane (augmente seuil excitabilité)

22
Q

Brivaracetam

A

Ca
Augmentation transmission inhibitrice (++)
Diminution transmission excitatrice

Bref : liaison SV2a (protéines vésicules synaptiques)

Nerveux 3 - 1 (2 decks)

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