Mod4 Flashcards

1
Q

Role of the Pentose phosphate pathway

A
  • produce NADPH
  • generate ribose-5-phosphate (a five carbon sugar, name of the pathway) - sugar component for nucleotides (DNA and RNA)
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2
Q

Currency of reducing power for most reductive biosynthetic reactions

A

NADPH

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3
Q

Starting point of the pathway

A

Glucose 6 P

(Interconnects PPP w glycolysis)

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4
Q

PPP carried out in the ____

A

Cytosol

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5
Q

Equivalent of PPP in plants (to make NADPH)

A

Photosynthesis

(In animals, PPP active in tissues where the synthesis of biomolecules occurs at high rates)

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6
Q

Oxidative phase

A

G6P gets oxidized and NADPH is produced (NADP+ reduced)

  • G6P —> 6-Phosphogluconolactone —> 6-Phosphogluconate —> Ribulose-5-Phosphate + CO2
  • Enzymes:
    (1) G6P Dehydrogenase: oxidized G6P, NADP+ reduced to NADPH

(2) Lactonase

(3) 6-phosphogluconate dehydrogenase: another NADPH produced

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7
Q

Non oxidative phase

A
  • Ribulose-5-P converted to Ribose-5-P
  • interconversion of 3-, 4-, 5-, 6-, and 7-carbon sugars (a way for the excess 5 carbon sugars to be converted to glycolysis intermediates)
  • no NADPH formed
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8
Q

Second major product of the pathway

A

Ribose-5-P

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9
Q

Number of NADPH produced for every G6P entering the ppp pathway

A

2

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10
Q

Ribulose-5-P

A

5 carbon sugar, end product of the oxidative phase

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11
Q

What enzyme converts ribulose5P to Ribose5P

A

Phosphopentose isomerase

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