Mod 1-4 Flashcards
8 Branches of Genetics
Behavioral Genetics, Biochemical Genetics, Cytogenetics, Developmental Genetics, Evolutionary Genetics, Molecular Genetics, Population Genetics, Quantitative Genetics
5 Applications of Genetics
Plant, Animal, and Microbial Improvement, Medicine, Legal Counselling, Legal Application, Genetic Engineering
The term Genetics was coined by who in 1905
William Bateson
The Greek word ‘gen’ means
“to become” or “to grow into something”
Branch of Biology that deals with heredity and variation
Genetics
Refers to the transmission of traits from parents to offspring. It provides the basis for similarities.
Heredity
Refers to the differences among individuals
Variation
Most fascinating field of Biology
Genetics
The principal determinants of life processes
Genes
A unifying principle in Biology.
Genetics
Three inter-related but broad fields of genetics
Transmission genetics, molecular genetics, population genetics
Also knows as “Classical Genetics”
Transmission genetics
This subdivision of genetics covers the basic principles of genetics (connection between heredity and chromosomes, location and arrangement of gene in a chromosome, gene maping)
Transmission genetics
The focus of this field is on the individual organism from acquisition of traits, genetic make-up, and how it passes on its genes to the next generation
Transmission Genetics
This field delves into the chemical nature of the gene
Molecular Genetics
Molecular genetics revolve around the central cellular processes namely:
Replication, transcription, translation
This field is concerned with studies that describe genetic changes over time and how genetic composition and population dynamics implicate evolution
Population genetics
It (the field) focuses on genetic makeup of individuals of the SAME SPECIES
Population genetics
Studies chromosomes, the visible carriers of DNA
Cytogenetics
Studies how heredity and environmental influences affect behavior
Behavioral Genetics
Studies how genetic variation leads to speciation and adaptation
Evolutionary Genetics
Studies the changes in genes and allele frequencies in populations over space and time
Population Genetics
Studies how genes control the growth and development of an organism
Developmental Genetics
Studies the relationship of genes and their control over functions of an enzyme in a metabolic pathway
Biochemical Genetics
Studies the role of genetics and the environment on inheritance of quantitative traits
Quantitative Genetics
Studies structure and function of genes at a molecular level
Molecular Genetics
The Father of Genetics
Gregor Mendel
Discovered hereditary “factors” which we now refer to as GENES
Gregor Mendel
Observed and predicted transmission of traits across generations
Gregor Mendel
Conclusion of Gregor Mendel
(1) gene is passed from parents to successive generations in a predictable fashion
(2) gene codes for information that would determine structure, function, and other biological properties
Prior to Mendel’s time, heredity was thought to be
a “blending” process
What hypothesis cannot account for cases when children resembled only one of the parents
Blending
Theory that says all organisms originated from miniature forms of themselves
Preformation theory
the pre-formed small human body that can be found in either ovum or sperm
homunculus
Greek philosopher that rejected the notion that offspring is pre-formed in either the “seed (or homunculus)” of ovum and sperm.
Aristotle
For types of causes for existence
Material, Final, Formal, Efficient causes
He proposed that semen was formed everywhere. He referred to a female’s menstrual blood as female semen
Aristotle
According to Aristotle, the male parent provided the
nature of individual
According to Aristotle, the female parent provided the
supportive environment
Formal cause begins the
Developmental process
According to Aristotle, what is the conveyor of inheritance
Blood or semen
Proponent of Theory of Pangenesis
Charles Darwin
Pan from Pangenesis means?
whole
Genesis from Pangenesis means
origin
He discussed his mechanism of heredity through
gemmules
unit of inheritance according to Darwin
gemmules
gemmules is a diminutive word of
gemma
gemma means
bud
minute particles that are shed by cells of an organism
gemmules
What completed theory of evolution
Pangenesis
Theory of Evolution has been widely accepted while Theory of Genesis is largely thought as
wrong
Basis of Pangenesis
Theory of Inheritance of Acquired Characteristics
Proposed to be the fundamental mechanism of evolution
Theory of Inheritance of Acquired Characteristics
It states that as an organism adapt to its environment, modifications to the organisms will arise. Such modifications are automatically handed down to descendants.
Theory of Inheritance of Acquired Characteristics
Theory of Inheritance of Acquired Characteristics
Jean Baptiste de Lamarck
Proponent of Germplasm Theory
August Weismann
Sex cells (or germplasm) perpetuated during reproduction generation after generation
Germplasm Theory
Second most notable evolutionary theorist after darwin
August Weismann
Theory that illustrated how gametes (germ cells - sperm cells or sperm cells) but not somatic cells function as agents of heredity
Germplasm Theory
During what does idantss of germplasm in the zygote doubles
amphimixis
basis or foundation of Classical or Transmission Genetics
Blending
Other scientists who studied Biological inheritance
Naudin, Gartner, Kolreuter, Dzierzon
One scientist who also took into account numerical rations in their methodologies
Dzierzon
Rediscoverers of Mendel
Hugo de Vries (Netherlands)
Erick von Tschermak (Austria)
Carl Correns (Germany)
Showed Mendel’s Principles also apply to animals, not just plants
William Bateson
Edith Rebecca Saunders
Lucien Cuenot
Associated Mendelian factors to physical structures we call ‘chromosomes’
Walter S. Sutton (USA)
Theodor Boveri (Germany)
Confirmed association of genes and chromosomes and demonstrated that MANY GENES ARE HOUSED IN EACH OF THE CHROMOSOMES
Thomas Hunt Morgan
Calvin B. Bridges
what played roles in the structure, function, and evolution of all organisms
genes
Who identified that DNA is the genetic material
Oswald T. Avery
Collin M. Macleod
Maclyn McCarty
Who identified that DNA is the genetic material
Oswald T. Avery
Collin M. Macleod
Maclyn MacCarty
Responsible for the elucidation of the molecular structure of the DNA (DNA Double Helix)
James D. Watson
Francis H.C. Crick
X-ray diffraction and crystallography of DNA
Maurice Wilkins
Rosalind Franklin
Gave better understanding of how genes are transmitted across generations and how they are expressed in individuals or in a population
Crystallography of DNA
Rapid progress in MOLECULAR GENETICS gave rise to disciplines such as
Molecular Biology
Synthetic Biology
Requires knowledge of Mathematics, Statistics, Biochemistry, and Ecology, among others TO ESTABLISH ORDERLY VARIETY OF PATTERNS of patterns and changes in living forms over time
Evolutionary genetics
Need staining technologies, applied physics, advanced microscopy, and imaging techniques to be able to address problems concerning INDIVIDUAL ABNORMALITIES
Cytogenetics
Employ knowledge of Ecology, Math, or Statistics
Population Genetics
Asses population dynamics and the changes in gene and allele frequencies
Quantitative Genetics
Utilize learnings from physiology, morpho-anatomy, and biochemistry to explain how individuals of THE SAME OR DIFF SPECIES WOULD DEVELOP and HOW THEY MAINTAIN THEIR OWN UNIQUE PATTERN AND ABILITY O EXIST CONTINUALLY
Developmental Genetics
Knowledge of inheritance of both desirable and undesirable characterstics in family
Genetic counselling
DNA profiles or fingerprints
Legal application
Greater opportunities to realize genetic gain, stable increases, and better production
Recombinant DNA Technology
Improving crops, domestic animals, and microorganisms
Selective Hybridization and breeding
Basic unit of life
Cell
genetic material in nuclear zone is also referred to as
nucleoid
genetic material in nuclear zone not enclosed in distinct bound nucleus and freely suspended in cytoplasm
Prokaryotic cell
Contain intracellular membranes, a true nucleus, and intracellular compartments
Eukaryotic cells
intracellular components are also known as
organelles
Genetiic material is in the form of
Chromatin
Compact form of chromatin
chromosome
housed within the nucleus, separated from the cytoplasm by a nuclear membrain
chromosome
conspicuous domain in nucleus which serve as a site for producing and assembling the cell’s ribosomes
Nucleolus
Sample of Prokaryotic cell
Bacteria
Cyanobacteria
Sample of Eukaryotic cell
Protist
Fungi
Plants
Animals
Size of prokaryotic cell
1-10 um
Size of eukaryotic cell
10-100 um
Cell division of Prokaryotic cell
Binary fission
Cell division of Eukaryotic cell
Mitosis and Meiosis
a double-membrane structure that is the primary director of cellular activity and inheritance
nucleus