MOCK PAPERS Flashcards
What type of chemicals are potentially most toxic to humans?
Both natural and human-made chemicals are potentially toxic to humans
Most important causes for clinical trial failures?
Toxicity
Clinical safety
Clinical efficacy
Most suitable methods to know if given drug has been metabolised normally in particular patient/s
HPLC (UV/MS)
And
HPLC (UV)
When DDT pesticide:
https://canvas.bham.ac.uk/courses/53141/files/11057257/preview
Enters human body, what happens?
IT is fat soluble and can be stored in fat tissue
Example of phase 1 metabolism?
Aromatic hydroxylation
What is secondary pharmacology a cause for?
Secondary pharmacology is a cause for toxicity
Which metabolic reactions can occur when catalysed by CYP450?
N-oxidation, S-oxidation Dealkylation (N-, O-, S-) Dehalogenation Aliphatic and aromatic hydroxylation Deamination
Which analytical method would indicate if the API (active pharmaceutical ingredient) is in the correct physical form?
X-Ray Powder Diffraction
In DSC graph, what is likely source of first peak?
Desolvation of water
which analytical method most suitable for info on content of blood sample?
NMR LCMS IR XRPD DSC
LCMS?
