MoA anti-diabetic drugs Flashcards
sulfonylureas eg gliclazide
depolarise islet cells in the pancreas increasing insulin release
thiazolidinediones eg pioglitazone
increase peripheral insulin sensitivity
SGLT-2 inhibitors eg dapgliflozin
increase urinary glucose loss
DPP4-inhibitors eg sitagliptin
inhibits GLP-1 breakdown
GLP-1 analogues eg exenatide
increase insulin secretion and sensitivity
acarbose
delay intestinal carbohydrate absorption
metformin eg biguanide
increases insulin sensitivity and decreases liver production of glucose
what drugs are involved in the release of incretins
DPP4
GLP1
what are some rapid acting insulins
novorapid
humalog
apidra
> start working after around 10 minutes and last about 4 hours
what are some short acting insulins
actrapid
humulin S
insuman rapid
> 30minutes - 8 hours
intermediate insulins
insulatard
humulin I
> 1hour - 16 hours
long acting insulins
lantus
levemir
> 1hour- 24 hours
long acting insulins
lantus
levemir
> 1hour- 24 hours
