MOA ABX Flashcards
MOAs (broad)
Inhibitors of CW synthesis
Inhibitors of protein synthesis
Inhibitors of CM fx
Inhibitors of nucleic acid synthesis
Inhibitors of metabolism
Antivirals
Inhibits peptidoG synthesis by inhibiting formation of cross links between polymers of CW by binding to PBP
Beta lactam
Ex: penicillin, cephalosporin
Acts poorly against GROWING peptidoG
Gram pos efficacy
Low toxicity
Generally bactericidal
Beta lactam
Ex: penicillin, cephalosporin
Resistance to beta lactam can occur how?
Change to pores (prevents entrance)
Modified PBP structure(prevents BL binding)
Beta lactamase hydrolysis
An inhibitor of CW synthesis
Binds to cross link peptide to prevent elongation (prevent completion)
Vancomycin
Inhibitor of CW synthesis
Blocks phospholipid carrier of subunits
Bacitracin
Inhibitor of CW synthesis
Inhibits mycolic acid formation
Isoniazid (INH)
Inhibitors of Cell Wall Syntheis mnemonic
Vanco
Beta lactam
Isoniazid
Bacitracin
Inhibitors of protein synthesis
Chloramphenicol/Clinda
Macrolides
Aminoglycosides
Tetracyclines
Inhibits polypeptide elongation by binding to 50s (blocks peptide bond formation)
Bacteriostatic
Broad-spec
Resistance can result from chemical change in abx or ribosomal subunit
Chloramphenicol
Clindamycin
Binds to 50s subunit
Prevents translocation
Macrolide
Inhibit translation by binding to 30s= misreading & incomplete synthesis
Bactericidal
Broad spectrum (used moreso on Gram Neg)
Resistance is from enzymatic alteration of abx
Aminoglycoside
Blocks binding of tRNA to 30S complex
Bacteristatic
Broad spectrum
Resistance from abx efflux or protective proteins from bacteria
Tetracyclines
Inhibitors of cell membrane fx
Polymyxin
Amphotericin B
Disrupts functional integrity of CM (detergent-like)
Cell membrane function inhibitors