MOA

Question 1

Beta-Lactams (Carbapenems, PCN’s, Cephalosporins)

Answer 1

Inhibition of cell wall synthesis by binding to transpeptidases (penicillin-binding proteins), which prevents cross-iini<ing
of peptidoglycan

Question 2

Glycopeptides (Vancomycin)

Answer 2

Inhibition of cell wall synthesis by binding to the molecules, which are the cell wall building blocks

Question 3

Aminoglycosides (Gentamicin)

Answer 3

Inhibition of protein synthesis by binding to the bacterial ribosome and disrupting mRNA translation

Question 4

Tetracyclines (Doxycycline)

Answer 4

Inhibition of protein synthesis by binding to the bacterial ribosome and preventing elongation of the peptide chain

Question 5

Macrolides (Erythromycin)

Answer 5

Inhibition of protein synthesis by disrupting ribosomai transiocation

Question 6

Chloramphenicol

Answer 6

Inhibition of protein synthesis by binding to the ribosome and inhibiting tRNA attachment

Question 7

Oxazolidinones (Linezolid)

Answer 7

Protein synthesis inhibitor by binding to the bacterial ribosome and preventing formation of the initiation complex

Question 8

Rifamycins (Rifampicin)

Answer 8

Binding to and inhibition of bacterial RNA poiymerase

Question 9

Quinolones (Ciprofloxacin)

Answer 9

Inhibition of DNA synthesis via inhibition of DNA gyrase and topoisomerase iV

Question 10

Diamlnopyrimidines (Trimethoprim)

Answer 10

Reduction of folic acid synthesis via inhibition of dihydrofolate reductase (inhibition of nucleic acid synthesis)

Question 11

Sulphonamides (Sulphamethoxazole)

Answer 11

Reduction of folic acid synthesis by competitive inhibition of p-aminobenzoic acid (inhibition of nucleic acid synthesis)

Question 12

Nitroimidazoles (Metronidazole)

Answer 12

Formation of radicals that cause DNA strand breakage

Question 13

Polymyxins (Colistin)

Answer 13

Disruption of cell membrane by interaction with membrane phosphoiipids

Question 14

Lipopeptides (Daptomycin)

Answer 14

Disruption of cell membrane