ADE

Question 1

Aminoglycosides (Gentamycin)

Answer 1

Ototoxicity and Nephrotoxicity

Question 2

Chloramphenicol

Answer 2

Aplastic anemia
‘Grey baby syndrome’ (abdominal distension, pallid cyanosis, circulatory collapse in neonates with immature hepatic function)

Question 3

Clindamycin

Answer 3

Diarrhoea; pseudomembranous colitis

Question 4

Co-trimoxazole (trimethoprim and sulphamethoxazole)

Answer 4

Hyperkalemia, Blood dyscrasias including myelosuppression (rare) and Stevens Johnson syndrome (rare)

Question 5

Daptomycin

Answer 5

Myositis; eosinophilic pneumonia

Question 6

Glycopeptides (Vancomycin)

Answer 6

Red man syndrome: (with rapid infusion) Nephrotoxicity; ototoxicity; neutropenia

Question 7

Linezolid

Answer 7

Myelosuppression
Optic neuropathy (particularly if used for>28 days)

Question 8

Macrolides (clarithromycin)

Answer 8

Prolongation of QT interval

Question 9

Metronidazole

Answer 9

Disulfiram-type reaction with alcohol Peripheral neuropathy (prolonged courses)

Question 10

Nitrofurantoin

Answer 10

Peripheral neuropathy

Question 11

Quinolones

Answer 11

Tendonitis, including tendon rupture
Lowered seizure threshold
Prolongation of QT interval (especially moxifloxacin)

Question 12

Rifampicin

Answer 12

Hepatotoxicity

Question 13

Tetracydines, esp. minocycline

Answer 13

Hepatotoxicity; irreversible pigmentation, Photosensitivity and dyspepsia
Lupus erythematosus-like syndrome