MOA

Question 1

Dopamine antagonist

Answer 1

Blocks D2 receptor in CTZ and GIT to reduce nausea

Question 2

5HT3 antagonist

Answer 2

Blocks 5HT3 serotonin receptors in GIT, CTZ and higher cortex

Question 3

Alutab

Answer 3

Contains Al(OH)3 binds to acid neutralises it

Question 4

Gaviscon

Answer 4

Contains CaCO3 binds to acids neutralising it

Question 5

Proton pump inhibitor

Answer 5

Blocks H+/K+ ATPase preventing acid secretion

Question 6

H2 receptor antagonist

Answer 6

Blocks H2 receptor on parietal cells inhibiting gastric acid secretion

Question 7

Mucosal strengthener

Answer 7

Synthetic prostaglandin analogue decreases gastric secretion and increases mucosal blood flow and secretion

Question 8

Aminosakicylates

Answer 8

Is a prodrug converted to active mesalazine in colon. Inhibits COX and lipoxygenase pathways and scavenges free radicals

Question 9

Glucocorticoids

Answer 9

Binds to nuclear receptor forming a complex which translocates to the nucleus and inhibits gene synthesis of inflammatory genes

Question 10

Amoxicillin

Answer 10

Inhibits penicillin binding protein and crosslinks peptidoglycan in bacterial cell synthesis

Question 11

Clarityromycin

Answer 11

Inhibits bacterial protein synthesis

Question 12

Metronidazole

Answer 12

Inhibits DNA synthesis in anaerobic bacteria

Question 13

Biologics

Answer 13

TNF signalling

Question 14

Immunomodulators

Answer 14

Nucleotide synthesis pathways

Question 15

Anti-cholinergics

Answer 15

Blocks M receptors in GIT muscles and parietal cells. Opposes effects of Ach to decrease peristalsis and reduce diarrhoea

Question 16

Opioids

Answer 16

Agonist of opioid u receptors on neurone in myenteric plexus, inhibiting Ach release, increasing segmentations and fluid absorption