Contraindications

Question 1

Dopamine antagonist

Answer 1

Involuntary muscle contractions with facial/skeletal muscle spasms, increase bowel motility

Question 2

5HT3 antagonist

Answer 2

No serious side effects, headache & constipation

Question 3

Alutab

Answer 3

Diarrhoea

Question 4

Gaviscon

Answer 4

Fluid retention

Question 5

Proton pump inhibitor

Answer 5

Diarrhoea, headache, dizzy, nausea, flatulence. Long term - bone fracture, malabsorption, susceptible to bacterial infeections

Question 6

H2 receptor antagonist

Answer 6

Diarrhoea, headache, dizzy

Question 7

Mucosal strengthener

Answer 7

Diarrhoea, cramps, headache, dizzy, nausea, flatulence

Question 8

Aminosalicylates

Answer 8

Headache, nausea, fatigue, minimised by giving with meals or use mesalazine. Rarely fever, hepatitis, bone marrow suppression, blood disorder

Question 9

Glucocorticoids

Answer 9

Overdose or prolonged use can cause hypertension, Na+/water retention, K+/Ca2+ loss. Diabetes, osteoporosis, growth suppression, Cushing’s syndrome, immunosupression. allergies, abnormal taste, antibiotic induced colitis

Question 10

Clarityromycin

Answer 10

Pregnancy & cardiac problems, CYP3A4 drug interactions, allergies, abnormal taste, antibiotic induced colitis

Question 11

Metronidazole

Answer 11

High dose/long term use - CNS & kidney toxicity, carcinogen, pre-term birth, allergies, abnormal taste, antibiotic induced colitis

Question 12

Osmotic laxatives

Answer 12

Flatulence, cramps

Question 13

Pro-kinetic/stimulants

Answer 13

Locally acting so low systemic side effects

Question 14

Anti-cholinergics

Answer 14

Systemic side effects - blurred vision, dry mouth, dizzy, hallucinations, excitations/confusion in elderly

Question 15

Opioids

Answer 15

Constipation, intestinal paralysis, CNS depression