MOA Flashcards
List the beta lactam antibiotics and their MOA
Amoxicillin, Flucloxacillin, Phenoxymethylpenicllin, Cefalexin,
MOA: binds to the penicillin binding protein in the cell wall preventing cross linking of peptidoglycan layer
Also, bactericidal
What is the MOA of clarithromycin?
Inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit (bacteriostatic)
What is the MOA of metronidazole?
Inhibits protein synthesis by interacting with DNA, causes a loss of helical structure and strand breakage (bactericidal)
MOA of Ciprofloxacin
Inhibits bacterial DNA synthesis by blacking DNA gyrase and to poison erase 4 (bactericidal)
Doxycycline MOA
Stops the growth of bacteria by binding to the 30S prokaryotic ribosomal unit during protein synthesis (bacteriostatic)
MOA of Trimethoprim/Sulfamethoxazole
Competitively inhibits bacterial folate production essential for bacterial growth (bacteriostatic)
MOA of Famciclovir
Following phosphorylation by viral and cellular enzymes, it inhibits viral DNA polymerase and DNA synthesis
Valciclovir MOA
Following phosphorylation by viral and cellular enzymes, it inhibits viral DNA polymerase and DNA synthesis
Acyclovir
Following phosphorylation by viral and cellular enzymes, inhibits viral DNA polymerase and DNA synthesis
Fluconazole MOA
Impairs the synthesis of ergosterol in fungal cell membranes leading to their breakdown, cell leakage and death occur by lytic activity of host defence system
Miconazole MOA
Impairs the synthesis of ergosterol in the fungal cell membrane leading to its breakdown, cell leakage and death occur by lytic activity of the host defence system
Amphoteracin B MOA
Binds irreversibly to ergosterol in fungal cell membranes causing cell death by altering their permeability and allowing leakage of intercellular components
