MOA Flashcards
Benzodiazepines
Bind to receptor sites on Y-amino butyric acid(GABA)
SSRI
Blocks reuptake of serotonin
SNRI
Blocks re-take of serotonin and norepinephrine
TCAs
Blocks reuptake of norepinephrine OR serotonin
MAOIs
Prevent enzymes from breaking down catacholamines
Bipolar agents
Unknown
Antipsychotics
Blocks dopamine receptors in dopamine pathways
Sedatives
Interact with gaba-benzodiazepine receptor complexes
ADHD
Stimulates CND activity; blocks re-take and increases release of norepinephrine and dopamine in neuronal space
Hydantoins
Binding to voltage dependant sodium channels
Valproates
Enhanced inhibitory actions of gaba
Divalproex
Valproic acid
Iministilbenes
Unknown
Carbamazepine
Y aminobutryric acid analogs
Increases GABA turnover without binding to the GABA receptor
Gabapentin
Prevailing
Tiagabine
Other seizure meds
Inhibits voltage dependant sodium channels
Lamotrigine
Levetiracetam
Topiramate
Zonisamide
Barbiturates for seizures
Enhances GABA receptors by binding GABA receptors to barbiturate receptors
Phenobarbital
Primidone
Parkinsons- amantidine
Stimulates release of dopamine from neuronal stores
Parkinsons-Benztropine
Anticholinergic-blocks action of acetylcholine
Parkinsons-Bromocriptine, pramipexole, ropinirole
Dopamine agonist
Parkinsons- levodopa/carbidopa
Synthesis if dopamine inside the brain and blocks conversion outside the brain
Parkinsons- levidopa/carbidopa/entacapone
Synthesis of dopamine inside the brain plus COMT conversion
Parkinsons- rasagiline, selegiline
Blocks degradation of dopamine by inhibiting MAOI
