MMR Flashcards

1
Q

Measles morphology

A

RNA virus
Paramyxo virus
helical nucleocapsid
Envelope with two projections
1) Haemagglutinin(H protein) for attachment to host cell
2) F protein for fusion of viral envelope with plasma membrane of host cell

NA lack

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2
Q

Cultivation of measles virus

A

in tissue culture, growth detected by CPE ( mutinucleated gaint cells intranuclear and intracytoplasmic inclusion bodies COWDRY type Awithin 7-10 days)

human amnion and chorion cell

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3
Q

Pathogenesis of measles virus

A

MOT via respiratory tract
entry — multiply locally— LN—Viremia— RE cells—secondary viremia— tropism for epithelial surfaces (skin res tract conjuntiva)—focal replication

replication in lymphocytes—disseminated throughout body

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4
Q

Clinical findings in measles

A

Prodromal phase 2 to4 days
— 3C — fever sneezing runny nose coughing conjunctivitis

Kolpik spotsin mouth 2 days before the rash (pathognomonic in measles)
-small bluish white ulcerations on buccal mucosa opposite the lower molars
lymphopenia

Eruptive phase 5-7 days
Maculopapular rash (cephalocaudal)
lightpink discrete —> brownish brotches

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5
Q

Complications of measles

A

Otitis media
Pneumoia secondary bac infection
Giant cell pneumonia
Neurologic complications
1 ) acute encephalitis
2 ) post infectious encephalomyelitis PIE
3 ) measles inclusion body encephalitis MIBE
4 ) subacute sclerosing panenphelitis SSPE

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6
Q

Vaccine for measles

A

Lifelong immunity
Live attenuated measles virus vaccine
MR
MMR
MMRV
1st dose 15 months or 12 months in high risk areas

CI - pregnancy allergy to eggs and neomycin
Immunocompromised except HIV
Recent administration of immunoglobulin

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7
Q

Mumps

A

acute contagious disease with non suppurative enlargement of one or both parotid glands

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8
Q

Morphology of mumps

A

RNA virus
virion
helical nucleocapsid
envelope with two projections
1) HA
2) NA

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9
Q

Pathogenesis of mumps

A

via respiratory tract
nasal and upper respiratory tract epithelial cells — viremia — salivary glands testes ovary pancreas thyroid kidneys CNS

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10
Q

Clinical findings of mumps

A

Prodromal— malaise anorexia
Enlargement of parotid and salivary glands
low grade fever pain in salivary glands

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11
Q

Complications of mumps

A

Aseptic meningitis
Meningoencephalitis
Deafness
Orchitis
Oophritis
Pancreatitis

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12
Q

Vaccination of mumps

A

Live attenuated mumps virus vaccines
Children over 1yr
MR
MMR

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13
Q

Rubella morphology

A

Togaviridae
RNA virus
Icosahedral symmetry nucleocapsid
Envelope with projection HA

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14
Q

Character of rubella

A

Acute febrile illness with rash
Posterior auricular and sub occipital lymphadenopathy

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15
Q

Clinical findings of rubella

A

Low grade fever
Morbilliform rash on the same day as fever
Rash starts on face— trunk— extremities
Lymphadenopathy posterior auricular and subocciital
Arthralgia and arthritis in women

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16
Q

Immunity and vaccination of rubella

A

Life long immunity
IgM IgG
Live attenuated vaccine 15 months

CI in pregnancy
Immunocompromised host

17
Q

Immunity and vaccination of rubella

A

Life long immunity
IgM IgG
Live attenuated vaccine 15 months

CI in pregnancy
Immunocompromised host

18
Q

Complications of rubella

A

Meningoencephalitis
Cataract blindness
Lungs heart GI

19
Q

Congenital rubella syndrome

A

Mother to fetus
Growth rate of infected cells reduced
Fewer number of cells in effected organs at birth
Deranged and hypoplastic organ development
Clinical findings—>
Transient eff— growth retardation, Meningoencephalitis, hepatosplenomegaly, thrombocytopenic purpura

Permanent eff— **CHD PDA ASD VSD* AS PS
eye blindness cataracts glaucoma chorioretinitis
Deafness

Developmental abnormalities
mental retardation
progressive rubella pan encephalitis