MMR Flashcards
Measles morphology
RNA virus
Paramyxo virus
helical nucleocapsid
Envelope with two projections
1) Haemagglutinin(H protein) for attachment to host cell
2) F protein for fusion of viral envelope with plasma membrane of host cell
NA lack
Cultivation of measles virus
in tissue culture, growth detected by CPE ( mutinucleated gaint cells intranuclear and intracytoplasmic inclusion bodies COWDRY type Awithin 7-10 days)
human amnion and chorion cell
Pathogenesis of measles virus
MOT via respiratory tract
entry — multiply locally— LN—Viremia— RE cells—secondary viremia— tropism for epithelial surfaces (skin res tract conjuntiva)—focal replication
replication in lymphocytes—disseminated throughout body
Clinical findings in measles
Prodromal phase 2 to4 days
— 3C — fever sneezing runny nose coughing conjunctivitis
Kolpik spotsin mouth 2 days before the rash (pathognomonic in measles)
-small bluish white ulcerations on buccal mucosa opposite the lower molars
lymphopenia
Eruptive phase 5-7 days
Maculopapular rash (cephalocaudal)
lightpink discrete —> brownish brotches
Complications of measles
Otitis media
Pneumoia secondary bac infection
Giant cell pneumonia
Neurologic complications
1 ) acute encephalitis
2 ) post infectious encephalomyelitis PIE
3 ) measles inclusion body encephalitis MIBE
4 ) subacute sclerosing panenphelitis SSPE
Vaccine for measles
Lifelong immunity
Live attenuated measles virus vaccine
MR
MMR
MMRV
1st dose 15 months or 12 months in high risk areas
CI - pregnancy allergy to eggs and neomycin
Immunocompromised except HIV
Recent administration of immunoglobulin
Mumps
acute contagious disease with non suppurative enlargement of one or both parotid glands
Morphology of mumps
RNA virus
virion
helical nucleocapsid
envelope with two projections
1) HA
2) NA
Pathogenesis of mumps
via respiratory tract
nasal and upper respiratory tract epithelial cells — viremia — salivary glands testes ovary pancreas thyroid kidneys CNS
Clinical findings of mumps
Prodromal— malaise anorexia
Enlargement of parotid and salivary glands
low grade fever pain in salivary glands
Complications of mumps
Aseptic meningitis
Meningoencephalitis
Deafness
Orchitis
Oophritis
Pancreatitis
Vaccination of mumps
Live attenuated mumps virus vaccines
Children over 1yr
MR
MMR
Rubella morphology
Togaviridae
RNA virus
Icosahedral symmetry nucleocapsid
Envelope with projection HA
Character of rubella
Acute febrile illness with rash
Posterior auricular and sub occipital lymphadenopathy
Clinical findings of rubella
Low grade fever
Morbilliform rash on the same day as fever
Rash starts on face— trunk— extremities
Lymphadenopathy posterior auricular and subocciital
Arthralgia and arthritis in women