H Influenzae+ General Flashcards
H influenzae morpho and antigenic structure
Virulence factors 4
Culture
morpho —-> gram(-) bacilli capsulated
enriched media—> blood loving bacilli
Antigenic structure—> capsule PRP polyribitol ribose phosphate ,somatic Ag, endotoxin
virulent factors 4 ခု
1. polyribose phosphate capsule( antiphagocytic)
2. Adhesive factor Pili
3. IgA1 protease
4. Lipopolysaccharide lipid
culture - chocolate agar grayish brown colonies
growth characteristics Factor X(hemin)and V(vitamin NAD) produced by staphylococcus
* Satellite phenomenon
Antigen detection by which test ? — Latex agglutination test
H influenzae diseases
invasive —> meningitis, fluminant obstructive laryngotreacheitis which present with cherry red epiglottitis
non invasive—> sinusitis otitis media pneumonia exacerbates COPD
meningitis in 5 months to 5 years old
Not in 3 months due to serum Ab from mother
Vaccinations of h influenzae
Hib vaccine H.influenzae type B conjugate vaccine at 2,4,6 months or 2,4 + booster bet: 12 and 15 months
Strep. pyogenes
Gram(+) cocci aranged in long chains
- Bld agar
- B-hemolysis
- Bacitracin sensitive
Ag: M protein (major virulent factor)
Cell wall (-) phagocytosis
Toxins
- Streptokinase (plasminogen → plasmin— bd clots bac escapes)
- DNase (degrade DNA)
- Hyaluronidase (bd hyaluronic acid-CT)
- pyrogenic exotoxins— toxic shock syndrome and scarlet fever
- hemolysin (Streptolysin Oand S> lyse RBC mem
ASO antibodies
Sore throat
S pyogenes
S aureus
Influenza
Cosackie
Rhino
Echo
Corona
Sore throat with exudate
Coryne — Diphtheria
Vicent angina— fuso borrelia
EB virus — glandular fever
Croup
Laryngotreachobronchitis in young children
Harsh barking non productive cough
Steeple sign
Virus
- Parainfluenza
- Adeno
- CMV
- EB
Bac
- S. pyogenes
- Coryne
-H influenzae
-bordetella
Lymphocytosis
Bordetella pertussis
White blood cell count is high
Due to capsule (antiphagocytic)
