Mitosis Flashcards
What are the two types of cell division
Mitosis and Meiosis
What is mitosis needed for
Growth of multicellular organisms and repairing damaged tissues
Do all cells regain the ability to divide?
No
What occurs in the cell cycle
Synthesis - Gap phase - Mitosis - Gap phase 2 -
How many stages does Mitosis have
4
What happens in Interphase
The cell carries out normal functions, but also prepares to divide:
- Cells DNA unravelled + replicated (double genetic content)
- Organelles are also replicated
- ATP content increased (energy needed for cell division)
What are the stages of Mitosis
1: Prophase
2: Metaphase
3: Anaphase
4: Telophase
What happens in Prophase
- Chromosomes condense (shorter and fatter)
- Centrioles start moving to opposite ends of the cell
- Centrioles form spindle fibres
- Nuclear envelope breaks down and chromosomes lie free in the cytoplasm.
What is a centriole
Tiny bundles of protein
What is a nuclear envelope
The membrane around the nucleus
What happens in Metaphase
- The chromosomes (each with two chromatids) line up along the middle of the cell and become attached to the spindle by their centromere
What happens in Anaphase
- The centromeres divide, separating each pair of sister chromatids
- the spindles contract, pulling chromatids to opposite ends of the spindle, centromere first
- Makes the chromatids appear v-shaped
What happens in Telophase
- Chromatids reach the opposite poles on the spindle
- They uncoil and become long and Thin
- They’re called chromosomes again
- A nuclear envelope forms around each group of chromosomes, now there are 2 nuclei
- The cytoplasm divides (cytokinesis) and there are now two daughter cells
- Daughter cells start interphase ready for start of mitosis
How to calculate the length of mitosis
Example:
100 cells undergoing mitosis. 10 of which are in metaphase. This suggests that the proportion of cells in metaphase must be 10/100th of the cell cycle. You’re told the cell cycle lasts 15 hours. (15*60) = 900 mins. 10/100 * 900 is 90 mins in metaphase.
How does cancer form
Uncontrolled cell division.