Mitochondrial Genome, Epigenetics, and NcRNA - Venk Flashcards
Approximately how many genes mitochondrial genome contains?
a) 1000
b) 1
c) 37
d) 23,000
e) 0
c) 37 genes
that can make proteins, tRNA’s and rRNA
Which of the following compounds can inhibit prokaryotic translation that has side effects with mitochondrial translational machinery?
a) streptomycin
b) tetracyline
c) erthyromycin
d) allopurinol
e) 5-flurouracil
c) erthyromycin
which is an rcRNA
What are the three ways in which chromatins can be remodeled by histone methylation mechanisms?
Phosphorylation at the Serine residues.
Ubiquitination and N-acetylation of Lysine residues
Methylation of Lysine and Arginine residues
What are the two resides of histones that get methylated?
Lysine-N and Arginine-N
The three epigenetic steps of histone methyl modification involve writing, erasing and reading. Describe the components of each step.
1) Writing is the Methylation of histones.
2) Erasing is the Demethylation of histones.
3) Reading is being able to identify Methyl pattern recognition
DNA [5’-CpG-3’] islands are controlled by _________ of cytosine.
methylation
Deamination of cytosine forms ___________.
Uracil.
Deamination of 5-methyl cytosine forms _____________.
It becomes Thymine
Which of the following proteins is “not” synthesized in the pancreas?
a) albumin
b) amylase
c) elactase
d) chymotrypsin
e) lipase
a) albumin
True or False: Noncoding RNA pairs to mRNA and suppresses translation.
True?…
True or False: Micro RNA is a type of noncoding RNA that suppresses transcription.
False. MicroRNA (MiRNA) is a small nuclear RNA (snRA) that can shut down TRANSLATION.
Which of the following compounds can inhibit prokaryotic transcription (more than one may apply)?
a) streptomycin
b) tetracyline
c) erthyromycin
d) allopurinol
e) 5-flurouracil
a) streptomycin
b) tetracyline
RNAi can be used for what in medicine?
- macular degeneration
- degeneration of Hep A and B genes
- Silencing of Influenza Gene Expression
- Neuro-Degenerative Diseases.
