mitochondria - resp. chain and uncoupling Flashcards
1
Q
What is the predominating lipid in inner membrane of mitochondria?
A
cardiolipid
2
Q
What occurs in the matrix of the membrane?
A
TCA, B-oxidation, urea cycle, ketogenesis
3
Q
How do mitochondria produce energy?
A
NADH, FADH2 production, electron transport and H+ gradient generation, phosphorylation of ATP
4
Q
What are the 5 complexes of the electron transport chain?
A
NADH CoQ oxidoreductase Succinate CoQ oxidoreductase CoQ cytochome bc1 oxidoreducase Cytochome c oxidase FoF1 ATPase
5
Q
Which complex has no mt DNA?
A
complex II
6
Q
List inhibitors of the respiratory chain and their acting complex.
A
Rotenone - complex I malonate - complex II antimycin - complex III azides, "-caine" cyanide - complex IV anthraquinone and oligomycin - complex V
7
Q
Fes is not a prosethic group of which complex?
A
IV
8
Q
What is the role of CoQ or ubiquinone?
A
To shuttle e-‘s from complex I OR II to complex II
9
Q
What is the role of cytochome c?
A
to shuttle electrons from complex III to IV
10
Q
What is the role of ANT?
A
cataylze exchange of ADP for ATP across the inner mt membrane
