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x Virology Term 2 Post-quiz Jen > Miscellaneous Virology > Flashcards

Miscellaneous Virology Flashcards

1
Q

Mechanism of HPV?

A

viral inactivation of cellular tumor suppressor gene

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2
Q

treat CMV with…

A

gencyclovir

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3
Q

lethal encephalitis associated with…

A

measles

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4
Q

most common viral cause of sporadic encephalitis is…

A

HSV1

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5
Q

EEV most commonly appears when?

A

focal outbreaks during summer

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6
Q

Pt in africa. presents with swelling in neck and jaw, blood + for heterophile antibody. test for what?

A

HIV and malaria

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7
Q

SV40 virus in polio vaccine…. what is possible prolem?

A

could cause cancer via alteration of tumor suppressor gene

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8
Q

Rous sarcroma causes cancer how?

A

proto-oncogenes

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9
Q

CMV is transmitted how…

A

fecal-oral route. wash hands after diaper changes!

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10
Q

What is least effective immune response against extracellular bacterial pathogens?

A

cytotoxic T cells

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11
Q

a delayed hypersensitivity reaction to PCN would take how long?

A

7 days

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12
Q

problems with bone marrow transplant

A

graft v host disease, host cells are replaced by donor cells

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13
Q

how can the lineage of leukeia cells be determined?

A

by tumor CD antigens

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14
Q

a tumor expressed by a papilloma virus expresses:

A

unique TSA, and same tumor antigens as another tumor induced by a papilloma virus

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15
Q

delayed hypersensitivity reactions are most often characterized by..

A

an infiltrate composed of T helper cells and macrophages

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16
Q

inflammation caused by immune compleses: requires what response?

A

neutrophils, and involves IgG and IgM

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17
Q

how quickly will macrophages produce TNF

A

within a few mins to an hour

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18
Q

what form of vaccine is most likely to induce CTL response?

A

modified life-measles vaccine

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19
Q

immune complexes can trigger platelet activation: T or F?

A

True

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20
Q

HLA disease association in autoimmunity may in soem cases be useful for diagnosis

A

hmm

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21
Q

with a second exposure to poison ivy, what will contribute to inflamation?

A

TNFalpha

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22
Q

Patients who lack C5-C9 have a high incidence of infection caused by what

A

Neisseria (bacterium)

23
Q

complement receptors on RBCs faciliate what?

A

elimination of immune complexes by phagocytic cells

24
Q

does coxsackie virus present with diarrhea, vomiting?

A

NO

25
Q

can polio vaccine mutate?

A

yes, reason why live attenuated is sometimes not given?

26
Q

alpha interferon: contributes to hepatitis clinical outcome how?

A

upregulates cellular kinase

27
Q

If get a needle stick from a patient with Hep B and Hep C, what is your main concern?

A

50% chance Hep C. Use a triple-drug cocktail

28
Q

Rotavirus. describe genome and freq of recomb

A

mult segments of dsDNA. freq recomb

29
Q

where does polio replicate?

A

cytoplasm of infected cells

30
Q

How would you diagnose Hep B (mild form that does not result in long term liver damage)

A

IgM antibody levels

31
Q

what causes an antigenic shift?

A

reassortment of different RNA segments in genome

32
Q

how would I distinguish croup v influenza?

A

structure of the genome

33
Q

do we routinely inject children with rotavirus vaccine?

A

yes

34
Q

if a child is exposed to Hep A, would that result in lifelong immunity?

A

yes

35
Q

with Hep E, will the feces contain a high number of virions?

A

yes

36
Q

Test results to interpret:
NL AST.
negative HBeAG and HBSAG.
Positive antibodies to HBeAG and HBsAg

A

Conclusion: HepB infection with subsequent recovery.

37
Q

what organ is both primary and seconday lymphoid organ?

A

bone marrow

38
Q

what is the primary signalling component associated with the T cell receptor?

A

CD3

39
Q

what does NOT inhibit the complement cascade?

A

Factor B

40
Q

TH1 cells produce what, and do what kind of immunity?

A

produce IFN gamma, and are part of cell-mediated imm

41
Q

TH2 cells produce what, and do what kind of imm?

A

IL4, and antibody mediated imm

42
Q

IgE: evolved to be anti-helminth

A

ok

43
Q

an example of molecular cross-reactivity?

A

strep/rheumatic fecer

44
Q

during what stages of B cell dev can tolerance most easily be developed?

A

immature cell stage, mature cell stage

45
Q

IgG diversity will not be created by…

A

class switching

46
Q

cell of the innate imm system do NOT respond to antigen by

A

clonal expansion

47
Q

what do Treg cells to to T cell activation in the periphery?

A

control it

48
Q

the primary APCs that initiate activation of naive T cells are?

A

DCs

49
Q

The processing of an antigen for MHC I presentation involves what?

A

a proteosome and the invariant chain

50
Q

CD28 binds to what to provide cell costimulation?

A

CD80

51
Q

if you have a defective poly Ig receptor, you will get recurrent bacterial infections at mucosal sites

A

ok

52
Q

T and B cells use what to exit from blood to lymph nodes?

A

HEVs

53
Q

a defect in CD154 will result in what?

A

defective B cell activation, and no IgG in serum

54
Q

The process of T cell development depends on what?

A

TCR binding to MHC molecules

x Virology Term 2 Post-quiz Jen (4 decks)

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