Miscellaneous Virology Flashcards
Mechanism of HPV?
viral inactivation of cellular tumor suppressor gene
treat CMV with…
gencyclovir
lethal encephalitis associated with…
measles
most common viral cause of sporadic encephalitis is…
HSV1
EEV most commonly appears when?
focal outbreaks during summer
Pt in africa. presents with swelling in neck and jaw, blood + for heterophile antibody. test for what?
HIV and malaria
SV40 virus in polio vaccine…. what is possible prolem?
could cause cancer via alteration of tumor suppressor gene
Rous sarcroma causes cancer how?
proto-oncogenes
CMV is transmitted how…
fecal-oral route. wash hands after diaper changes!
What is least effective immune response against extracellular bacterial pathogens?
cytotoxic T cells
a delayed hypersensitivity reaction to PCN would take how long?
7 days
problems with bone marrow transplant
graft v host disease, host cells are replaced by donor cells
how can the lineage of leukeia cells be determined?
by tumor CD antigens
a tumor expressed by a papilloma virus expresses:
unique TSA, and same tumor antigens as another tumor induced by a papilloma virus
delayed hypersensitivity reactions are most often characterized by..
an infiltrate composed of T helper cells and macrophages
inflammation caused by immune compleses: requires what response?
neutrophils, and involves IgG and IgM
how quickly will macrophages produce TNF
within a few mins to an hour
what form of vaccine is most likely to induce CTL response?
modified life-measles vaccine
immune complexes can trigger platelet activation: T or F?
True
HLA disease association in autoimmunity may in soem cases be useful for diagnosis
hmm
with a second exposure to poison ivy, what will contribute to inflamation?
TNFalpha
Patients who lack C5-C9 have a high incidence of infection caused by what
Neisseria (bacterium)
complement receptors on RBCs faciliate what?
elimination of immune complexes by phagocytic cells
does coxsackie virus present with diarrhea, vomiting?
NO
can polio vaccine mutate?
yes, reason why live attenuated is sometimes not given?
alpha interferon: contributes to hepatitis clinical outcome how?
upregulates cellular kinase
If get a needle stick from a patient with Hep B and Hep C, what is your main concern?
50% chance Hep C. Use a triple-drug cocktail
Rotavirus. describe genome and freq of recomb
mult segments of dsDNA. freq recomb
where does polio replicate?
cytoplasm of infected cells
How would you diagnose Hep B (mild form that does not result in long term liver damage)
IgM antibody levels
what causes an antigenic shift?
reassortment of different RNA segments in genome
how would I distinguish croup v influenza?
structure of the genome
do we routinely inject children with rotavirus vaccine?
yes
if a child is exposed to Hep A, would that result in lifelong immunity?
yes
with Hep E, will the feces contain a high number of virions?
yes
Test results to interpret:
NL AST.
negative HBeAG and HBSAG.
Positive antibodies to HBeAG and HBsAg
Conclusion: HepB infection with subsequent recovery.
what organ is both primary and seconday lymphoid organ?
bone marrow
what is the primary signalling component associated with the T cell receptor?
CD3
what does NOT inhibit the complement cascade?
Factor B
TH1 cells produce what, and do what kind of immunity?
produce IFN gamma, and are part of cell-mediated imm
TH2 cells produce what, and do what kind of imm?
IL4, and antibody mediated imm
IgE: evolved to be anti-helminth
ok
an example of molecular cross-reactivity?
strep/rheumatic fecer
during what stages of B cell dev can tolerance most easily be developed?
immature cell stage, mature cell stage
IgG diversity will not be created by…
class switching
cell of the innate imm system do NOT respond to antigen by
clonal expansion
what do Treg cells to to T cell activation in the periphery?
control it
the primary APCs that initiate activation of naive T cells are?
DCs
The processing of an antigen for MHC I presentation involves what?
a proteosome and the invariant chain
CD28 binds to what to provide cell costimulation?
CD80
if you have a defective poly Ig receptor, you will get recurrent bacterial infections at mucosal sites
ok
T and B cells use what to exit from blood to lymph nodes?
HEVs
a defect in CD154 will result in what?
defective B cell activation, and no IgG in serum
The process of T cell development depends on what?
TCR binding to MHC molecules
