Miscellaneous Metabolism Questions

Question 1

What 2 proteins can xport urea to the liver?

Answer 1

Glutamate and alanine

Question 2

During urea formation, NH2 from various AA’s are deaminated (w/alpha-ketaglutarate) to form ______________, which is made into these 2 molecules that will form urea.

Answer 2

• Glutamate

- Ammonia, aspartate

Question 3

What molecules are required for purine biosynthesis?

Answer 3

• Aspartate, glutamine, glycine

- N10-formyl-THF

Question 4

What molecules are required for pyrimidine biosynthesis?

Answer 4

• Aspartate, glutamine

- CO2

Question 5

What are the only 2 simple precursors necessary to make heme?

Answer 5

• Glycine and succinyl-CoA (ALA synthase –> ALA)

Question 6

Besides PDH, what 2 enzymes would be affected by a riboflavin deficiency?

Answer 6

• Succinate DH

- Acyl-CoA DH

Question 7

What enzymes are associated w/folic acid (B9) deficiency?

Answer 7

• Thymidylate synthase

- Methionine synthase (homocysteine methyltransferase)

Question 8

What enzymes are associated w/cobalamin (B12) deficiency?

Answer 8

• Methomalonyl-CoA mutase (^ urinary MMA)

- Methionine synthease

Question 9

What enzyme does arsenic inhibit?

Answer 9

PDH