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FHB GI > Lipoproteins > Flashcards

Lipoproteins Flashcards

1
Q

Chylomicron: main lipid(s)?

A

TAG

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2
Q

Chylomicron: apoproteins?

A

B-48, (A, C, E)

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3
Q

Chylomicron: function(s)?

A

Transports dietary TAG to adipose, etc (skin, heart, SkM)

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4
Q

Chylomicron Remnant: main lipid(s)?

A

TAG

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5
Q

Chylomicron Remnant: apoproteins?

A

B-48, (A, C, E)

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6
Q

Chylomicron Remnant: function(s)?

A
  • Delivers remaining TAG to the liver

- Exchanges TAG for CE from HDL; deliver CE to the liver

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7
Q

VLDL: main lipid(s)?

A

TAG

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8
Q

VLDL: apoproteins?

A

B-100, (A, C, E)

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9
Q

VLDL: function(s)?

A
  • Transports endogenously synthesized TAG to adipose tissue and to heart m. + SkM
  • Exchanges TAG for CE from HDL
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10
Q

IDL: main lipid(s)?

A

TAG + cholesterol

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11
Q

IDL: apoproteins?

A

B-100, E

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12
Q

IDL: function(s)?

A
  • Delivers remaining TAG and cholesterol to the liver

- Exchanges remaining TAG for CE from HDL; deliver CE to the liver

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13
Q

LDL: main lipid(s)?

A

Cholesterol

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14
Q

LDL: apoproteins?

A

B-100

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15
Q

LDL: function(s)?

A

Delivers cholesterol to liver and other cells, including steroidogenic cells

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16
Q

HDL: main lipid(s)?

A

Cholesterol

17
Q

HDL: apoproteins?

A

A’s, (C, E)

18
Q

HDL: function(s)?

A
  • Accepts cholesterol from peripheral cells, esterifies it, and transports the CEs to the liver
  • Exchanges CE for TAG in VLDL, IDL, and chylomicron remnants
  • Atheroprotective via enzymes such as paraoxonase that inhibit LDL oxidation
  • Serves as a reservoir for circulating apoproteins (A, C, E), which are transported to other lipoprotein particles
19
Q

Apoprotein B-48: Major LP?

A

Chylomicron

20
Q

Apoprotein B-48: Function(s)?

A

Chylomicron secretion (structural)

21
Q

Apoprotein B-100: Major LP?

A

VLDL, IDL, LDL

22
Q

Apoprotein B-100: Function(s)?

A
  • VLDL and LDL secretion (structural)

- Binds LDL receptor (found on hepatic and non-hepatic tissue)

23
Q

Apoprotein A-1: Major LP?

A

HDL

24
Q

Apoprotein A-1: Function(s)?

A
  • Cofactor for LCAT activation (lecithin cholesterol acyl transferase)
  • Binds HDL receptor
25
Q

Apoprotein C-II: Major LP?

A

Chylomicron, VLDL, IDL, HDL

26
Q

Apoprotein C-II: Function(s)?

A
  • Cofactor for lipoprotein lipase activation
27
Q

Apoprotein E: Major LP?

A

Chylomicron, VLDL, IDL, HDL

28
Q

Apoprotein E: Function(s)?

A
  • Clearance via binding to LRP (LDL receptor related protein)
    (- binds remnant receptor)
29
Q

Total cholesterol should be less than:

A

200 mg/dL

30
Q

What lipids (and their %s) make up “total cholesterol”?

A

100% HDLs
100% LDLs
20% TAGs

31
Q

Total HDL should be greater than or equal to:

A

60 mg/dL

32
Q

Total LDL should be less than:

A

100 mg/dL

33
Q

Total TAG should be less than:

A

100 mg/dL

34
Q

An optimal lipid ratio is:

give details

A

200 (total) / 60 (HDL) = 3.3 : 1

FHB GI (10 decks)

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